{(R)-6-[(1S,3S)-3-((R)-1,5-Dimethyl-hexyl)-cyclopentyl]-3-methyl-hexyloxymethyl}-benzene

Base Information

• Chemical Name: {(R)-6-[(1S,3S)-3-((R)-1,5-Dimethyl-hexyl)-cyclopentyl]-3-methyl-hexyloxymethyl}-benzene
• CAS No.: 600167-90-6
• Molecular Formula: C₂₇H₄₆O
• Molecular Weight: 386.662
• Mol file: 600167-90-6.mol

Synonyms:{(R)-6-[(1S,3S)-3-((R)-1,5-Dimethyl-hexyl)-cyclopentyl]-3-methyl-hexyloxymethyl}-benzene

Chemical Property of {(R)-6-[(1S,3S)-3-((R)-1,5-Dimethyl-hexyl)-cyclopentyl]-3-methyl-hexyloxymethyl}-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(R)-6-[(1S,3S)-3-((R)-1,5-Dimethyl-hexyl)-cyclopentyl]-3-methyl-hexyloxymethyl}-benzene

There total 9 articles about {(R)-6-[(1S,3S)-3-((R)-1,5-Dimethyl-hexyl)-cyclopentyl]-3-methyl-hexyloxymethyl}-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{(R)-6-[(1R,4S)-4-((R)-1,5-Dimethyl-hexyl)-cyclopent-2-enyl]-3-methyl-hexyloxymethyl}-benzene → {(R)-6-[(1S,3S)-3-((R)-1,5-Dimethyl-hexyl)-cyclopentyl]-3-methyl-hexyloxymethyl}-benzene (600167-90-6)

Guidance literature:

With sodium acetate; toluene-4-sulfonic acid hydrazide; In 1,2-dimethoxyethane; water; for 2h; Heating;

DOI:10.1002/anie.200250629

Reference yield:

(3R)-citronellol (1117-61-9) → {(R)-6-[(1S,3S)-3-((R)-1,5-Dimethyl-hexyl)-cyclopentyl]-3-methyl-hexyloxymethyl}-benzene (600167-90-6)

Guidance literature:

Multi-step reaction with 8 steps

1.1: NaH / 1,2-dimethoxy-ethane / 4 h / Heating

2.1: O₃

2.2: NaBH₄ / methanol; CH₂Cl₂ / 12 h / -78 - 20 °C

3.1: PPh₃; CBr₄ / diethyl ether / 12 h / 20 °C

4.1: Mg / tetrahydrofuran / 65 °C

4.2: CuBr*SMe₂ / tetrahydrofuran / -78 °C

4.3: 80 percent / tetrahydrofuran / 12 h / -78 - 20 °C

5.1: LiAlH₄ / tetrahydrofuran / 65 °C

6.1: pyridine / 0 °C

7.1: 85 percent / Li₂CuCl₄ / tetrahydrofuran / 12 h / -78 - 0 °C

8.1: TsNHNH₂; NaOAc / 1,2-dimethoxy-ethane; H₂O / 2 h / Heating

With pyridine; lithium aluminium tetrahydride; dilithium tetrachlorocuprate; carbon tetrabromide; sodium acetate; sodium hydride; ozone; magnesium; toluene-4-sulfonic acid hydrazide; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; water;

DOI:10.1002/anie.200250629

Reference yield:

benzyl bromide (100-39-0) → {(R)-6-[(1S,3S)-3-((R)-1,5-Dimethyl-hexyl)-cyclopentyl]-3-methyl-hexyloxymethyl}-benzene (600167-90-6)

Guidance literature:

Multi-step reaction with 8 steps

1.1: NaH / 1,2-dimethoxy-ethane / 4 h / Heating

2.1: O₃

2.2: NaBH₄ / methanol; CH₂Cl₂ / 12 h / -78 - 20 °C

3.1: PPh₃; CBr₄ / diethyl ether / 12 h / 20 °C

4.1: Mg / tetrahydrofuran / 65 °C

4.2: CuBr*SMe₂ / tetrahydrofuran / -78 °C

4.3: 80 percent / tetrahydrofuran / 12 h / -78 - 20 °C

5.1: LiAlH₄ / tetrahydrofuran / 65 °C

6.1: pyridine / 0 °C

7.1: 85 percent / Li₂CuCl₄ / tetrahydrofuran / 12 h / -78 - 0 °C

8.1: TsNHNH₂; NaOAc / 1,2-dimethoxy-ethane; H₂O / 2 h / Heating

With pyridine; lithium aluminium tetrahydride; dilithium tetrachlorocuprate; carbon tetrabromide; sodium acetate; sodium hydride; ozone; magnesium; toluene-4-sulfonic acid hydrazide; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; water;

DOI:10.1002/anie.200250629

upstream raw materials:

(3R)-citronellol

benzyl bromide

(R)-(+)-citronellyl benzyl ether

(3R)-1-benzyloxy-3-methyl-6-hexanol