(3R)-1-benzyl-3-hydroxy-6,6-dimethyl-3-trifluoromethyl-1,3,6,7-tetrahydropyrano[4,3-b]pyrrole-2,4-dione

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Chemical Name:(3R)-1-benzyl-3-hydroxy-6,6-dimethyl-3-trifluoromethyl-1,3,6,7-tetrahydropyrano[4,3-b]pyrrole-2,4-dione
CAS No.:1239620-02-0
Molecular Formula:C₁₇H₁₆F₃NO₄
Molecular Weight:355.314
Hs Code.:

Synonyms:(3R)-1-benzyl-3-hydroxy-6,6-dimethyl-3-trifluoromethyl-1,3,6,7-tetrahydropyrano[4,3-b]pyrrole-2,4-dione

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Chemical Property of (3R)-1-benzyl-3-hydroxy-6,6-dimethyl-3-trifluoromethyl-1,3,6,7-tetrahydropyrano[4,3-b]pyrrole-2,4-dione

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Technology Process of (3R)-1-benzyl-3-hydroxy-6,6-dimethyl-3-trifluoromethyl-1,3,6,7-tetrahydropyrano[4,3-b]pyrrole-2,4-dione

There total 1 articles about (3R)-1-benzyl-3-hydroxy-6,6-dimethyl-3-trifluoromethyl-1,3,6,7-tetrahydropyrano[4,3-b]pyrrole-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-benzylamino-6,6-dimethyl-5,6-dihydro-pyran-2-one

: 431-72-1
3,3,3-trifluoro-2-oxopropanoic acid

: 1239620-02-0
(3R)-1-benzyl-3-hydroxy-6,6-dimethyl-3-trifluoromethyl-1,3,6,7-tetrahydropyrano[4,3-b]pyrrole-2,4-dione

: (3S)-1-benzyl-3-hydroxy-6,6-dimethyl-3-trifluoromethyl-1,3,6,7-tetrahydropyrano[4,3-b]pyrrole-2,4-dione

Guidance literature:: 4-benzylamino-6,6-dimethyl-5,6-dihydro-pyran-2-one; 3,3,3-trifluoro-2-oxopropanoic acid; With titanium(IV) isopropylate; cinchonine; In dichloromethane; at 20 ℃; Inert atmosphere;

In dichloromethane; 1,2-dichloro-ethane; optical yield given as %ee; enantioselective reaction; Reflux; Inert atmosphere;
DOI:10.1002/chem.201000911

Reference yield: 68.0%

: 1239620-02-0
(3R)-1-benzyl-3-hydroxy-6,6-dimethyl-3-trifluoromethyl-1,3,6,7-tetrahydropyrano[4,3-b]pyrrole-2,4-dione

: 1239620-11-1
(3R,3aS,7aR)-1-benzyl-3-(trifluoromethyl)-tetrahydro-3-hydroxy-6,6-dimethylpyrano[4,3-b]pyrrole-2,4(1H,6H)-dione

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In acetic acid; at 20 ℃; for 50h; under 15201 Torr;
DOI:10.1002/chem.201000911