431-72-1

Usage

Uses

Used in Biotransformation Studies:
Trifluoropyruvic acid, monohydrate is used as a reagent in the biotransformation of pentafluoropropane in both rats and humans. This application is significant because it helps researchers understand the metabolic pathways and enzyme interactions involved in the conversion of pentafluoropropane, which can be useful in the development of new drugs and therapies.

InChI:InChI=1/C3H3F3O4/c4-2(5,6)1(7)3(8,9)10/h8-10H

Upstream product

• 7309-82-2 perfluoropyruvic acid fluoride 
• 10321-14-9 α,α-dihydroxytrifluoropropionic acid 
• 3821-82-7 α,β-Dihydroxy-α-trifluormethylpropionsaeure 
• 116-15-4 perfluoropropylene 
• 13081-18-0 ethyl-3,3,3-trifluoropyruvate 

Downstream Products

• 58457-64-0 3-(trifluoromethyl)quinoxalin-2(1H)-one 
• 1239619-88-5 (3S)-1-benzhydryl-3-hydroxy-3-trifluoromethyl-3,5,6,7-tetrahydro-1H-indole-2,4-dione 
• 1239619-87-4 (3R)-1-benzhydryl-3-hydroxy-3-trifluoromethyl-3,5,6,7-tetrahydro-1H-indole-2,4-dione 
• 1239619-89-6 (3R)-1-benzhydryl-3-hydroxy-6,6-dimethyl-3-trifluoromethyl-3,5,6,7-tetrahydro-1H-indole-2,4-dione 
• 1239619-90-9 (3S)-1-benzhydryl-3-hydroxy-6,6-dimethyl-3-trifluoromethyl-3,5,6,7-tetrahydro-1H-indole-2,4-dione 
• 1239620-02-0 (3R)-1-benzyl-3-hydroxy-6,6-dimethyl-3-trifluoromethyl-1,3,6,7-tetrahydropyrano[4,3-b]pyrrole-2,4-dione 
• 1239619-93-2 (3R)-spiro[cyclobutane-3',5',6',7',-[1H]-indole]1'-benzhydryl-3'-hydroxy-3-trifluoromethyl-2',4'-dione 
• 1239619-94-3 (3S)-spiro[cyclobutane-3',5',6',7',-[1H]-indole]1'-benzhydryl-3'-hydroxy-3-trifluoromethyl-2',4'-dione 
• 1239620-00-8 (3R)-spiro[cyclopentane-3',5',6',7'-[1H]-indole]1'-benzhydryl-3'-hydroxy-3'-trifluoromethyl-2',4'-dione 

Relevant academic research and scientific papers

HETEROCYCLIC DERIVATES, PREPARATION PROCESSES AND MEDICAL USES THEREOF

Disclosed are heterocyclic derivatives, methods for making them, compositions containing the same and uses thereof. Particularly, their pharmaceutical use as inhibitors of PARP is disclosed.

HETEROCYCLIC DERIVATES，PREPARATION PROCESSES AND MEDICAL USES THEREOF

Disclosed are heterocyclic derivatives, methods for making them, compositions containing the same and uses thereof. Particularly, their pharmaceutical use as inhibitors of PARP is disclosed.

Multiple Bonds between Atoms of Main Group Elements and Transition Metals, CVIII. - Stoichiometric and Catalytic Oxidation of Electron-poor Olefins with Osmium Tetraoxide: A Novel Oxidation Method for Fluoroolefins

In contrast to current opinion, osmium tetraoxide reacts even with very electron-poor olefins.For example, both partially and fully fluorinated osmate(VI) esters 2 are thus formed from fluoroolefins 1 by cycloaddition.Hydrolysis of the osmate(VI) esters leads to the corresponding 1,2-diols 3 and, eventually, consecutive fluoroorganic products by HF elimination.A catalytic version of this route opens a new, general, and efficient entry to oxidation products in fluoroolefin chemistry.Tetrahalide ethylene derivatives of formula split off oxalyl halide upon thermal treatment with the complexes py2O2OsX2 thus being formed in good yields. Key Words: Osmium tetraoxide, oxidation with / cis-Hydroxylation, catalytic / Fluoroolefins