5‐hydroxy‐8‐methoxy‐2-phenyl-7‐(4‐(pyrrolidin‐1‐yl)butoxy)‐4H‐chromen‐4‐one

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Chemical Name:5‐hydroxy‐8‐methoxy‐2-phenyl-7‐(4‐(pyrrolidin‐1‐yl)butoxy)‐4H‐chromen‐4‐one
CAS No.:1178583-19-1
Molecular Formula:C₂₄H₂₇NO₅
Molecular Weight:409.482
Hs Code.:

Synonyms:5‐hydroxy‐8‐methoxy‐2-phenyl-7‐(4‐(pyrrolidin‐1‐yl)butoxy)‐4H‐chromen‐4‐one

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Chemical Property of 5‐hydroxy‐8‐methoxy‐2-phenyl-7‐(4‐(pyrrolidin‐1‐yl)butoxy)‐4H‐chromen‐4‐one

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Technology Process of 5‐hydroxy‐8‐methoxy‐2-phenyl-7‐(4‐(pyrrolidin‐1‐yl)butoxy)‐4H‐chromen‐4‐one

There total 8 articles about 5‐hydroxy‐8‐methoxy‐2-phenyl-7‐(4‐(pyrrolidin‐1‐yl)butoxy)‐4H‐chromen‐4‐one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 123-75-1
pyrrolidine

: C₂₀H₁₉BrO₅

: 1178583-19-1
5‐hydroxy‐8‐methoxy‐2-phenyl-7‐(4‐(pyrrolidin‐1‐yl)butoxy)‐4H‐chromen‐4‐one

Guidance literature:: In acetonitrile; Reflux;
DOI:10.1016/j.bmcl.2016.12.076

Reference yield:

: 87-66-1
2-hydroxyresorcinol

: 1178583-19-1
5‐hydroxy‐8‐methoxy‐2-phenyl-7‐(4‐(pyrrolidin‐1‐yl)butoxy)‐4H‐chromen‐4‐one

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium iodide; potassium carbonate / acetone / 48 h / Reflux

2.1: nitric acid / acetic acid / 4 h / 40 °C

3.1: sodium dithionite / water; ethyl acetate / 1 h / 20 °C

4.1: ethanol / 0.17 h

4.2: 0.5 h / 20 °C

5.1: hydrogen; palladium 10% on activated carbon / methanol / 8 h / 20 °C

6.1: chloroform / 0.5 h / 20 °C

6.2: Reflux

7.1: iodine / dimethyl sulfoxide / 120 - 140 °C

8.1: aluminum (III) chloride / acetonitrile / 8 h / -5 - 0 °C / Reflux

9.1: potassium carbonate / acetone / 8 h / Reflux

10.1: acetonitrile / Reflux

With aluminum (III) chloride; sodium dithionite; palladium 10% on activated carbon; hydrogen; iodine; nitric acid; potassium carbonate; potassium iodide; In methanol; ethanol; chloroform; water; acetic acid; dimethyl sulfoxide; ethyl acetate; acetone; acetonitrile; 6.1: |Friedel-Crafts Acylation;
DOI:10.1016/j.bmcl.2016.12.076

Reference yield:

: 20032-42-2
2,5-dimethoxyresorcinol

: 1178583-19-1
5‐hydroxy‐8‐methoxy‐2-phenyl-7‐(4‐(pyrrolidin‐1‐yl)butoxy)‐4H‐chromen‐4‐one

Guidance literature:: Multi-step reaction with 5 steps

1.1: chloroform / 0.5 h / 20 °C

1.2: Reflux

2.1: iodine / dimethyl sulfoxide / 120 - 140 °C

3.1: aluminum (III) chloride / acetonitrile / 8 h / -5 - 0 °C / Reflux

4.1: potassium carbonate / acetone / 8 h / Reflux

5.1: acetonitrile / Reflux

With aluminum (III) chloride; iodine; potassium carbonate; In chloroform; dimethyl sulfoxide; acetone; acetonitrile; 1.1: |Friedel-Crafts Acylation;
DOI:10.1016/j.bmcl.2016.12.076