trans-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

Base Information

Chemical Name:trans-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine
CAS No.:1311266-99-5
Molecular Formula:C₂₃H₂₉NO₂
Molecular Weight:351.489
Hs Code.:

Synonyms:trans-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

Suppliers and Price of trans-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trans-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

There total 6 articles about trans-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1311266-79-1
trans-N-benzyl-3-methoxy-3,4-dihydrospiro-[[2]benzopyran-1,1`-cyclohexan]-4`-amine

: 1311266-99-5
trans-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; water; at 20 ℃; for 23h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.04.002

Reference yield:

: 112396-13-1
2-(2-bromophenyl)acetaldehyde dimethyl acetal

: 1311266-99-5
trans-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / chloroform; water / 1.33 h / 20 °C

3.1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / dichloromethane; water / 23 h / 20 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; hexane; dichloromethane; chloroform; water;
DOI:10.1016/j.bmc.2011.04.002

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 1311266-99-5
trans-N-benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / tetrahydrofuran / 16 h / -10 - 20 °C

2.1: toluene-4-sulfonic acid / 72 h / Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere

3.2: 3 h / -78 - 20 °C / Inert atmosphere

4.1: hydrogenchloride / chloroform; water / 1.33 h / 20 °C

5.1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

6.1: sodium tris(acetoxy)borohydride / dichloromethane; water / 23 h / 20 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; potassium tert-butylate; sodium tris(acetoxy)borohydride; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; hexane; dichloromethane; chloroform; water; 1.1: Wittig reaction;
DOI:10.1016/j.bmc.2011.04.002