5-acetyl-2-amino-6-methyl-4-(4-methyl-phenyl)-4H-pyran-3-carbonitrile

Base Information

• Chemical Name: 5-acetyl-2-amino-6-methyl-4-(4-methyl-phenyl)-4H-pyran-3-carbonitrile
• CAS No.: 120811-10-1
• Molecular Formula: C₁₆H₁₆N₂O₂
• Molecular Weight: 268.315
• Mol file: 120811-10-1.mol

Synonyms:5-acetyl-2-amino-6-methyl-4-(4-methyl-phenyl)-4H-pyran-3-carbonitrile

Chemical Property of 5-acetyl-2-amino-6-methyl-4-(4-methyl-phenyl)-4H-pyran-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 5-acetyl-2-amino-6-methyl-4-(4-methyl-phenyl)-4H-pyran-3-carbonitrile

There total 2 articles about 5-acetyl-2-amino-6-methyl-4-(4-methyl-phenyl)-4H-pyran-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-methyl-benzaldehyde (104-87-0) + acetylacetone (123-54-6,81235-32-7) + malononitrile (109-77-3) → 5-acetyl-2-amino-6-methyl-4-(4-methyl-phenyl)-4H-pyran-3-carbonitrile (120811-10-1)

Guidance literature:

With ClOZn^(1-)*2CH₄N₂O*C₅H₁₄NO⁽¹⁺⁾; In neat liquid; at 20 ℃; for 1.5h;

DOI:10.1007/s13738-017-1144-7

Reference yield: 56.0%

3-(4-methyl-benzylidene)-pentane-2,4-dione (15818-09-4) + malononitrile (109-77-3) → 5-acetyl-2-amino-6-methyl-4-(4-methyl-phenyl)-4H-pyran-3-carbonitrile (120811-10-1)

Guidance literature:

With triethylamine; In ethanol; Ambient temperature;

DOI:10.1016/S0040-4020(01)81443-5

Reference yield: 92.0%

5-acetyl-2-amino-6-methyl-4-(4-methyl-phenyl)-4H-pyran-3-carbonitrile (120811-10-1) → 5-acetyl-6-methyl-2-oxo-4-p-tolyl-1,2,3,4-tetrahydropyridine-3-carbonitrile

Guidance literature:

With formic acid; Ambient temperature;

upstream raw materials:

3-(4-methyl-benzylidene)-pentane-2,4-dione

malononitrile

4-methyl-benzaldehyde

acetylacetone

Downstream raw materials:

5-acetyl-6-methyl-2-oxo-4-p-tolyl-1,2,3,4-tetrahydro-pyridine-3-carbonitrile