1-ethyl-6-fluoro-3-(hydroxymethyl)-7,8-bis((4-methoxybenzyl)oxy)quinolin-4-(1H)-one

Base Information

Chemical Name:1-ethyl-6-fluoro-3-(hydroxymethyl)-7,8-bis((4-methoxybenzyl)oxy)quinolin-4-(1H)-one
CAS No.:1429439-72-4
Molecular Formula:C₂₈H₂₈FNO₆
Molecular Weight:493.532
Hs Code.:

Synonyms:1-ethyl-6-fluoro-3-(hydroxymethyl)-7,8-bis((4-methoxybenzyl)oxy)quinolin-4-(1H)-one

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Chemical Property of 1-ethyl-6-fluoro-3-(hydroxymethyl)-7,8-bis((4-methoxybenzyl)oxy)quinolin-4-(1H)-one

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Technology Process of 1-ethyl-6-fluoro-3-(hydroxymethyl)-7,8-bis((4-methoxybenzyl)oxy)quinolin-4-(1H)-one

There total 3 articles about 1-ethyl-6-fluoro-3-(hydroxymethyl)-7,8-bis((4-methoxybenzyl)oxy)quinolin-4-(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.3%

: 1429439-71-3
1-ethyl-6-fluoro-7,8-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid

: 1429439-72-4
1-ethyl-6-fluoro-3-(hydroxymethyl)-7,8-bis((4-methoxybenzyl)oxy)quinolin-4-(1H)-one

Guidance literature:: 1-ethyl-6-fluoro-7,8-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -78 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 1429439-72-4
1-ethyl-6-fluoro-3-(hydroxymethyl)-7,8-bis((4-methoxybenzyl)oxy)quinolin-4-(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / 4 h / 75 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.2: 1.5 h / -78 °C / Inert atmosphere

With triethylamine; potassium hydroxide; isobutyl chloroformate; In tetrahydrofuran;

Reference yield:

: 100501-62-0
ethyl 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

: 1429439-72-4
1-ethyl-6-fluoro-3-(hydroxymethyl)-7,8-bis((4-methoxybenzyl)oxy)quinolin-4-(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / 4 h / 75 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.2: 1.5 h / -78 °C / Inert atmosphere

With triethylamine; potassium hydroxide; isobutyl chloroformate; In tetrahydrofuran;