N-(5-amino-2-fluoro-4-methylphenyl)thiophene-3-carboxamide

Base Information

• Chemical Name: N-(5-amino-2-fluoro-4-methylphenyl)thiophene-3-carboxamide
• CAS No.: 1395923-75-7
• Molecular Formula: C₁₂H₁₁FN₂OS
• Molecular Weight: 250.297
• Mol file: 1395923-75-7.mol

Synonyms:N-(5-amino-2-fluoro-4-methylphenyl)thiophene-3-carboxamide

Chemical Property of N-(5-amino-2-fluoro-4-methylphenyl)thiophene-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-(5-amino-2-fluoro-4-methylphenyl)thiophene-3-carboxamide

There total 5 articles about N-(5-amino-2-fluoro-4-methylphenyl)thiophene-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

N-(2-fluoro-4-methyl-5-nitrophenyl)thiophene-3-carboxamide → N-(5-amino-2-fluoro-4-methylphenyl)thiophene-3-carboxamide (1395923-75-7)

Guidance literature:

With tin(ll) chloride; In ethanol; Reflux;

DOI:10.1021/acs.jmedchem.7b00745

Reference yield:

2-fluoro-4-methyl-5-nitro-phenylamine (259860-00-9) → N-(5-amino-2-fluoro-4-methylphenyl)thiophene-3-carboxamide (1395923-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride; phosgene; triethylamine / dichloromethane / 20 °C

2: palladium on activated charcoal; hydrogen / ethyl acetate / 20 °C

With phosgene; aluminum (III) chloride; palladium on activated charcoal; hydrogen; triethylamine; In dichloromethane; ethyl acetate;

DOI:10.1021/jm401276h

Reference yield:

3-Thiophene carboxylic acid (88-13-1) → N-(5-amino-2-fluoro-4-methylphenyl)thiophene-3-carboxamide (1395923-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride; phosgene; triethylamine / dichloromethane / 20 °C

2: palladium on activated charcoal; hydrogen / ethyl acetate / 20 °C

With phosgene; aluminum (III) chloride; palladium on activated charcoal; hydrogen; triethylamine; In dichloromethane; ethyl acetate;

DOI:10.1021/jm401276h

upstream raw materials:

2-fluoro-4-methyl-5-nitro-phenylamine

3-Thiophene carboxylic acid

2-fluoro-4-methylaniline

3-thiophene carboxylic acid chloride

Downstream raw materials:

C₂₆H₁₉FN₂O₃S

C₂₃H₂₁FN₂O₂S