1-[[3-(1,1-dimethylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid methyl ester

Base Information

Chemical Name:1-[[3-(1,1-dimethylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid methyl ester
CAS No.:1372890-94-2
Molecular Formula:C₂₄H₂₆F₃NO₄S
Molecular Weight:481.536
Hs Code.:

Synonyms:1-[[3-(1,1-dimethylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid methyl ester

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Chemical Property of 1-[[3-(1,1-dimethylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid methyl ester

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Technology Process of 1-[[3-(1,1-dimethylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid methyl ester

There total 3 articles about 1-[[3-(1,1-dimethylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 77758-51-1
methyl hex-5-ynoate

N-(2-iodo-4-(trifluoromethyl)-phenyl)-3-(1,1-dimethylethyl)-benzene-sulfonamide: 1203588-23-1
N-(2-iodo-4-(trifluoromethyl)-phenyl)-3-(1,1-dimethylethyl)-benzene-sulfonamide

: 1372890-94-2
1-[[3-(1,1-dimethylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid methyl ester

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; for 3h; Inert atmosphere; Reflux;

Reference yield:

: 2905-26-2
3-(tert-butyl)benzene-1-sulfonyl chloride

: 1372890-94-2
1-[[3-(1,1-dimethylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 4 h / 20 °C

2: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / Inert atmosphere; Reflux

With pyridine; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide;

Reference yield:

: 163444-17-5
2-iodo-4-(trifluoromethyl)aniline

: 1372890-94-2
1-[[3-(1,1-dimethylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 4 h / 20 °C

2: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / Inert atmosphere; Reflux

With pyridine; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide;