Technology Process of Nα-benzyloxycarbonyl-NG-(2,2,5,7,8-pentamethylchroman-6-sulphonyl)-arginylleucinyl-NG-(2,2,5,7,8-pentamethylchroman-6 sulphonyl)-arginylglycylglycine methyl ester
There total 5 articles about Nα-benzyloxycarbonyl-NG-(2,2,5,7,8-pentamethylchroman-6-sulphonyl)-arginylleucinyl-NG-(2,2,5,7,8-pentamethylchroman-6 sulphonyl)-arginylglycylglycine methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 53 percent / chlorosulphonic acid / CHCl3 / 1.) -5 deg C, 15 min 2.) -5 deg C -> rt, 1 h
2: 3.2 M sodium hydroxide / acetone / 1.) 0 deg C, 2 h 2.) rt, 2 h
3: 1.) diphenylphosphinyl chloride, NMM 2.) NMM, 2,6-lutidine / 1.) DCM, -5 deg C, 2 min 2.) DMF a) -10 deg C, 1 h b) -10 deg C -> rt, 3 h c) rt, 1 h
With
4-methyl-morpholine; 2,6-dimethylpyridine; chlorosulfonic acid; sodium hydroxide; Diphenylphosphinic chloride;
In
chloroform; acetone;
DOI:10.1016/S0040-4020(01)86564-9
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 44 percent / ZnCl2 / acetic acid / 1.) 23 deg C, 12 h 2.) 150 deg C, 7 h
2: 53 percent / chlorosulphonic acid / CHCl3 / 1.) -5 deg C, 15 min 2.) -5 deg C -> rt, 1 h
3: 3.2 M sodium hydroxide / acetone / 1.) 0 deg C, 2 h 2.) rt, 2 h
4: 1.) diphenylphosphinyl chloride, NMM 2.) NMM, 2,6-lutidine / 1.) DCM, -5 deg C, 2 min 2.) DMF a) -10 deg C, 1 h b) -10 deg C -> rt, 3 h c) rt, 1 h
With
4-methyl-morpholine; 2,6-dimethylpyridine; chlorosulfonic acid; sodium hydroxide; zinc(II) chloride; Diphenylphosphinic chloride;
In
chloroform; acetic acid; acetone;
DOI:10.1016/S0040-4020(01)86564-9
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 3.2 M sodium hydroxide / acetone / 1.) 0 deg C, 2 h 2.) rt, 2 h
2: 1.) diphenylphosphinyl chloride, NMM 2.) NMM, 2,6-lutidine / 1.) DCM, -5 deg C, 2 min 2.) DMF a) -10 deg C, 1 h b) -10 deg C -> rt, 3 h c) rt, 1 h
With
4-methyl-morpholine; 2,6-dimethylpyridine; sodium hydroxide; Diphenylphosphinic chloride;
In
acetone;
DOI:10.1016/S0040-4020(01)86564-9
