Trifluoro-methanesulfonic acid (S)-2-benzyloxymethoxy-propyl ester

Base Information

• Chemical Name: Trifluoro-methanesulfonic acid (S)-2-benzyloxymethoxy-propyl ester
• CAS No.: 174627-68-0
• Molecular Formula: C₁₂H₁₅F₃O₅S
• Molecular Weight: 328.309
• Mol file: 174627-68-0.mol

Synonyms:Trifluoro-methanesulfonic acid (S)-2-benzyloxymethoxy-propyl ester

Chemical Property of Trifluoro-methanesulfonic acid (S)-2-benzyloxymethoxy-propyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Trifluoro-methanesulfonic acid (S)-2-benzyloxymethoxy-propyl ester

There total 1 articles about Trifluoro-methanesulfonic acid (S)-2-benzyloxymethoxy-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + (S)-(+)-2-<(benzyloxy)methoxy>propan-1-ol (91191-94-5) → Trifluoro-methanesulfonic acid (S)-2-benzyloxymethoxy-propyl ester (174627-68-0)

Guidance literature:

With 2,6-di-tert-butyl-pyridine; In dichloromethane; at -78 ℃; for 0.5h;

DOI:10.1016/0040-4039(95)02353-4

Reference yield: 88.0%

1-((3aS,9bR)-3,3-Dimethyl-3a,9b-dihydro-3H,4H-chromeno[4,3-c]isoxazol-1-yl)-propan-1-one (168919-05-9) + Trifluoro-methanesulfonic acid (S)-2-benzyloxymethoxy-propyl ester (174627-68-0) → (2S,4S)-4-Benzyloxymethoxy-1-((3aS,9bR)-3,3-dimethyl-3a,9b-dihydro-3H,4H-chromeno[4,3-c]isoxazol-1-yl)-2-methyl-pentan-1-one

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hexamethylsilazane; In diethyl ether; toluene; at -78 ℃; for 0.5h;

DOI:10.1016/0040-4039(95)02353-4

Reference yield: 85.0%

1-((3aR,9bS)-3,3-Dimethyl-3a,9b-dihydro-3H,4H-chromeno[4,3-c]isoxazol-1-yl)-propan-1-one (169105-72-0) + Trifluoro-methanesulfonic acid (S)-2-benzyloxymethoxy-propyl ester (174627-68-0) → (2R,4S)-4-Benzyloxymethoxy-1-((3aR,9bS)-3,3-dimethyl-3a,9b-dihydro-3H,4H-chromeno[4,3-c]isoxazol-1-yl)-2-methyl-pentan-1-one

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hexamethylsilazane; In diethyl ether; toluene; at -78 ℃; for 0.5h;

DOI:10.1016/0040-4039(95)02353-4

upstream raw materials:

trifluoromethylsulfonic anhydride

(S)-(+)-2-<(benzyloxy)methoxy>propan-1-ol