(5S,6S)-1-Benzyl-6-benzyloxymethyl-5-methoxymethoxy-piperidine-2-thione

Base Information

Chemical Name:(5S,6S)-1-Benzyl-6-benzyloxymethyl-5-methoxymethoxy-piperidine-2-thione
CAS No.:165672-59-3
Molecular Formula:C₂₂H₂₇NO₃S
Molecular Weight:385.527
Hs Code.:

Synonyms:(5S,6S)-1-Benzyl-6-benzyloxymethyl-5-methoxymethoxy-piperidine-2-thione

Suppliers and Price of (5S,6S)-1-Benzyl-6-benzyloxymethyl-5-methoxymethoxy-piperidine-2-thione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5S,6S)-1-Benzyl-6-benzyloxymethyl-5-methoxymethoxy-piperidine-2-thione

Chemical Property:

Purity/Quality:

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Technology Process of (5S,6S)-1-Benzyl-6-benzyloxymethyl-5-methoxymethoxy-piperidine-2-thione

There total 8 articles about (5S,6S)-1-Benzyl-6-benzyloxymethyl-5-methoxymethoxy-piperidine-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 165672-58-2
(5S,6S)-1-Benzyl-6-benzyloxymethyl-5-methoxymethoxy-piperidin-2-one

: 165672-59-3
(5S,6S)-1-Benzyl-6-benzyloxymethyl-5-methoxymethoxy-piperidine-2-thione

Guidance literature:: With Lawessons reagent;
DOI:10.1016/0040-4039(95)00661-U

Reference yield:

: 92912-21-5
ethyl 1-benzyl-3,6-dioxo-2-piperidinecarboxylate

: 165672-59-3
(5S,6S)-1-Benzyl-6-benzyloxymethyl-5-methoxymethoxy-piperidine-2-thione

Guidance literature:: Multi-step reaction with 8 steps

1: 88 percent / baker's yeast / H₂O

2: 98 percent / Huenig base / CHCl₃ / Heating

3: 96 percent / Super-Hydride / tetrahydrofuran / 0 °C

4: 95 percent / n-Bu₃P, pyridine

5: 95 percent / Raney Ni (W-4) / ethanol

6: conc. HCl / methanol

7: 96 percent / NaH / dimethylformamide; benzene

8: 90 percent / Lawesson's reagent / tetrahydrofuran / Heating

With Lawessons reagent; pyridine; hydrogenchloride; baker's yeast; tributylphosphine; Raney Ni (W-4); sodium hydride; lithium triethylborohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo990397t

Reference yield:

: 165672-48-0
(2R,3S)-1-benzyl-3-methoxymethoxy-6-oxopiperidine-2-carboxylic acid ethyl ester

: 165672-59-3
(5S,6S)-1-Benzyl-6-benzyloxymethyl-5-methoxymethoxy-piperidine-2-thione

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / Super-Hydride / tetrahydrofuran / 0 °C

2: 95 percent / n-Bu₃P, pyridine

3: 95 percent / Raney Ni (W-4) / ethanol

4: conc. HCl / methanol

5: 96 percent / NaH / dimethylformamide; benzene

6: 90 percent / Lawesson's reagent / tetrahydrofuran / Heating

With Lawessons reagent; pyridine; hydrogenchloride; tributylphosphine; Raney Ni (W-4); sodium hydride; lithium triethylborohydride; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo990397t