1-tert-butyl 5-isopropyl 4-(2-allyl-5-nitrophenyl)-6-methyl-3-[2-diazo-2-[(methyloxy)carbonyl]-acetyl]-2-oxo-1,2,3,4-tetrahydro-1,5-pyrimidinedicarboxylate

Base Information

Chemical Name:1-tert-butyl 5-isopropyl 4-(2-allyl-5-nitrophenyl)-6-methyl-3-[2-diazo-2-[(methyloxy)carbonyl]-acetyl]-2-oxo-1,2,3,4-tetrahydro-1,5-pyrimidinedicarboxylate
CAS No.:313696-28-5
Molecular Formula:C₂₇H₃₁N₅O₁₀
Molecular Weight:585.571
Hs Code.:

1-tert-butyl 5-isopropyl 4-(2-allyl-5-nitrophenyl)-6-methyl-3-[2-diazo-2-[(methyloxy)carbonyl]-acetyl]-2-oxo-1,2,3,4-tetrahydro-1,5-pyrimidinedicarboxylate

Synonyms:1-tert-butyl 5-isopropyl 4-(2-allyl-5-nitrophenyl)-6-methyl-3-[2-diazo-2-[(methyloxy)carbonyl]-acetyl]-2-oxo-1,2,3,4-tetrahydro-1,5-pyrimidinedicarboxylate

Suppliers and Price of 1-tert-butyl 5-isopropyl 4-(2-allyl-5-nitrophenyl)-6-methyl-3-[2-diazo-2-[(methyloxy)carbonyl]-acetyl]-2-oxo-1,2,3,4-tetrahydro-1,5-pyrimidinedicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-tert-butyl 5-isopropyl 4-(2-allyl-5-nitrophenyl)-6-methyl-3-[2-diazo-2-[(methyloxy)carbonyl]-acetyl]-2-oxo-1,2,3,4-tetrahydro-1,5-pyrimidinedicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-tert-butyl 5-isopropyl 4-(2-allyl-5-nitrophenyl)-6-methyl-3-[2-diazo-2-[(methyloxy)carbonyl]-acetyl]-2-oxo-1,2,3,4-tetrahydro-1,5-pyrimidinedicarboxylate

There total 7 articles about 1-tert-butyl 5-isopropyl 4-(2-allyl-5-nitrophenyl)-6-methyl-3-[2-diazo-2-[(methyloxy)carbonyl]-acetyl]-2-oxo-1,2,3,4-tetrahydro-1,5-pyrimidinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 313696-26-3
isopropyl 4-(2-allyl-5-nitrophenyl)-3-[2-diazo-2-[(methyloxy)carbonyl]acetyl]-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

: 313696-28-5
1-tert-butyl 5-isopropyl 4-(2-allyl-5-nitrophenyl)-6-methyl-3-[2-diazo-2-[(methyloxy)carbonyl]-acetyl]-2-oxo-1,2,3,4-tetrahydro-1,5-pyrimidinedicarboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.3390/50300227

Reference yield:

: 542-08-5
isopropyl acetoacetate

: 313696-28-5
1-tert-butyl 5-isopropyl 4-(2-allyl-5-nitrophenyl)-6-methyl-3-[2-diazo-2-[(methyloxy)carbonyl]-acetyl]-2-oxo-1,2,3,4-tetrahydro-1,5-pyrimidinedicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 66 percent / AcOH; conc. HCl / 24 h / Heating

2: 47 percent / Pd(PPh₃)4 / toluene / 48 h / Heating

3: 71 percent / benzene / 2 h / Heating

4: 460 mg / MesN₂; Et₃N / CH₂Cl₂ / 20 °C

5: 90 percent / DMAP; Et₃N / CH₂Cl₂ / 2 h / 20 °C

With hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,4,6-trimethyl-benzenediazonium; acetic acid; triethylamine; In dichloromethane; toluene; benzene; 1: Biginelli reaction;
DOI:10.3390/50300227

Reference yield:

: 84459-32-5
2-bromo-5-nitrobenzaldehyde

: 313696-28-5
1-tert-butyl 5-isopropyl 4-(2-allyl-5-nitrophenyl)-6-methyl-3-[2-diazo-2-[(methyloxy)carbonyl]-acetyl]-2-oxo-1,2,3,4-tetrahydro-1,5-pyrimidinedicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 66 percent / AcOH; conc. HCl / 24 h / Heating

2: 47 percent / Pd(PPh₃)4 / toluene / 48 h / Heating

3: 71 percent / benzene / 2 h / Heating

4: 460 mg / MesN₂; Et₃N / CH₂Cl₂ / 20 °C

5: 90 percent / DMAP; Et₃N / CH₂Cl₂ / 2 h / 20 °C

With hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,4,6-trimethyl-benzenediazonium; acetic acid; triethylamine; In dichloromethane; toluene; benzene; 1: Biginelli reaction;
DOI:10.3390/50300227