isopropyl 4-(2-allyl-5-nitrophenyl)-3-[2-diazo-2-[(methyloxy)carbonyl]acetyl]-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Base Information

Chemical Name:isopropyl 4-(2-allyl-5-nitrophenyl)-3-[2-diazo-2-[(methyloxy)carbonyl]acetyl]-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
CAS No.:313696-26-3
Molecular Formula:C₂₂H₂₃N₅O₈
Molecular Weight:485.453
Hs Code.:

Synonyms:isopropyl 4-(2-allyl-5-nitrophenyl)-3-[2-diazo-2-[(methyloxy)carbonyl]acetyl]-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

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Chemical Property of isopropyl 4-(2-allyl-5-nitrophenyl)-3-[2-diazo-2-[(methyloxy)carbonyl]acetyl]-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

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Technology Process of isopropyl 4-(2-allyl-5-nitrophenyl)-3-[2-diazo-2-[(methyloxy)carbonyl]acetyl]-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

There total 6 articles about isopropyl 4-(2-allyl-5-nitrophenyl)-3-[2-diazo-2-[(methyloxy)carbonyl]acetyl]-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 313696-33-2
isopropyl 4-(2-allyl-5-nitrophenyl)-6-methyl-3-(2-methyloxycarbonylacetyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

: 313696-26-3
isopropyl 4-(2-allyl-5-nitrophenyl)-3-[2-diazo-2-[(methyloxy)carbonyl]acetyl]-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Guidance literature:: With 2,4,6-trimethyl-benzenediazonium; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.3390/50300227

Reference yield:

: 542-08-5
isopropyl acetoacetate

: 313696-26-3
isopropyl 4-(2-allyl-5-nitrophenyl)-3-[2-diazo-2-[(methyloxy)carbonyl]acetyl]-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / AcOH; conc. HCl / 24 h / Heating

2: 47 percent / Pd(PPh₃)4 / toluene / 48 h / Heating

3: 71 percent / benzene / 2 h / Heating

4: 460 mg / MesN₂; Et₃N / CH₂Cl₂ / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,4,6-trimethyl-benzenediazonium; acetic acid; triethylamine; In dichloromethane; toluene; benzene; 1: Biginelli reaction;
DOI:10.3390/50300227

Reference yield:

: 84459-32-5
2-bromo-5-nitrobenzaldehyde

: 313696-26-3
isopropyl 4-(2-allyl-5-nitrophenyl)-3-[2-diazo-2-[(methyloxy)carbonyl]acetyl]-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / AcOH; conc. HCl / 24 h / Heating

2: 47 percent / Pd(PPh₃)4 / toluene / 48 h / Heating

3: 71 percent / benzene / 2 h / Heating

4: 460 mg / MesN₂; Et₃N / CH₂Cl₂ / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,4,6-trimethyl-benzenediazonium; acetic acid; triethylamine; In dichloromethane; toluene; benzene; 1: Biginelli reaction;
DOI:10.3390/50300227