2-<3-<4-(2-ethoxyphenyl)-1-piperazinyl>butyryl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine

Base Information

• Chemical Name: 2-<3-<4-(2-ethoxyphenyl)-1-piperazinyl>butyryl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine
• CAS No.: 83100-00-9
• Molecular Formula: C₂₈H₃₈N₄O₂
• Molecular Weight: 462.635

Synonyms:2-<3-<4-(2-ethoxyphenyl)-1-piperazinyl>butyryl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine

Chemical Property of 2-<3-<4-(2-ethoxyphenyl)-1-piperazinyl>butyryl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine

Chemical Property:

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Technology Process of 2-<3-<4-(2-ethoxyphenyl)-1-piperazinyl>butyryl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine

There total 2 articles about 2-<3-<4-(2-ethoxyphenyl)-1-piperazinyl>butyryl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]-naphthyridine (83137-21-7) → 2-<3-<4-(2-ethoxyphenyl)-1-piperazinyl>butyryl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine (83100-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / pyridine / CHCl₃ / 1.) 5 deg C; 2.) r.t.

2: Triton B / ethanol / Heating

With pyridine; N-benzyl-trimethylammonium hydroxide; In ethanol; chloroform;

DOI:10.1248/cpb.32.3981

Reference yield:

1-(2-ethoxyphenyl)piperazine (13339-01-0) + 2-crotonoyl-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine (83099-99-4) → 2-<3-<4-(2-ethoxyphenyl)-1-piperazinyl>butyryl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine (83100-00-9)

Guidance literature:

With N-benzyl-trimethylammonium hydroxide; In ethanol; Heating;

DOI:10.1248/cpb.32.3981

Reference yield: 90.0%

2-<3-<4-(2-ethoxyphenyl)-1-piperazinyl>butyryl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine (83100-00-9) → 2-{3-[4-(2-Ethoxy-phenyl)-piperazin-1-yl]-butyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine (83081-84-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; Heating;

DOI:10.1248/cpb.32.3981

upstream raw materials:

1-(2-ethoxyphenyl)piperazine

2-crotonoyl-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine

1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]-naphthyridine

Downstream raw materials:

2-{3-[4-(2-Ethoxy-phenyl)-piperazin-1-yl]-butyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid

2-{3-[4-(2-Ethoxy-phenyl)-piperazin-1-yl]-butyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine

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