L-2-[2'-(3''-tert-butyl-5''-methyl-7''-oxo-7H-furo[3,2-g][1]benzopyran-6''-yl)-acetylamino]-3-phenylpropionic acid

Base Information

• Chemical Name: L-2-[2'-(3''-tert-butyl-5''-methyl-7''-oxo-7H-furo[3,2-g][1]benzopyran-6''-yl)-acetylamino]-3-phenylpropionic acid
• CAS No.: 956048-84-3
• Molecular Formula: C₂₇H₂₇NO₆
• Molecular Weight: 461.514

Synonyms:L-2-[2'-(3''-tert-butyl-5''-methyl-7''-oxo-7H-furo[3,2-g][1]benzopyran-6''-yl)-acetylamino]-3-phenylpropionic acid

Chemical Property of L-2-[2'-(3''-tert-butyl-5''-methyl-7''-oxo-7H-furo[3,2-g][1]benzopyran-6''-yl)-acetylamino]-3-phenylpropionic acid

Chemical Property:

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Technology Process of L-2-[2'-(3''-tert-butyl-5''-methyl-7''-oxo-7H-furo[3,2-g][1]benzopyran-6''-yl)-acetylamino]-3-phenylpropionic acid

There total 4 articles about L-2-[2'-(3''-tert-butyl-5''-methyl-7''-oxo-7H-furo[3,2-g][1]benzopyran-6''-yl)-acetylamino]-3-phenylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

(3'-tert-butyl-5'-methyl-7'-oxo-7H-furo[3,2-g][1]benzopyran-6'-yl)acetic acid (664366-05-6) + L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → L-2-[2'-(3''-tert-butyl-5''-methyl-7''-oxo-7H-furo[3,2-g][1]benzopyran-6''-yl)-acetylamino]-3-phenylpropionic acid (956048-84-3)

Guidance literature:

(3'-tert-butyl-5'-methyl-7'-oxo-7H-furo[3,2-g][1]benzopyran-6'-yl)acetic acid; With thionyl chloride; at 20 ℃;

L-phenylalanine; With triethylamine; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1016/j.ejmech.2011.07.032

Reference yield:

1-chloro-3,3-dimethyl-butan-2-one (13547-70-1) → L-2-[2'-(3''-tert-butyl-5''-methyl-7''-oxo-7H-furo[3,2-g][1]benzopyran-6''-yl)-acetylamino]-3-phenylpropionic acid (956048-84-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / water / 0.33 h / 130 °C / Microwave irradiation

2.1: isopropyl alcohol; sodium hydroxide / 4 h / Reflux

3.1: thionyl chloride / 20 °C

3.2: 20 °C

With thionyl chloride; triethylamine; isopropyl alcohol; sodium hydroxide; In water;

DOI:10.1016/j.ejmech.2011.07.032

Reference yield:

7-hydroxy-3-methoxycarbonylmethyl-4-methyl-2H-chromen-2-one (95903-37-0) → L-2-[2'-(3''-tert-butyl-5''-methyl-7''-oxo-7H-furo[3,2-g][1]benzopyran-6''-yl)-acetylamino]-3-phenylpropionic acid (956048-84-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / water / 0.33 h / 130 °C / Microwave irradiation

2.1: isopropyl alcohol; sodium hydroxide / 4 h / Reflux

3.1: thionyl chloride / 20 °C

3.2: 20 °C

With thionyl chloride; triethylamine; isopropyl alcohol; sodium hydroxide; In water;

DOI:10.1016/j.ejmech.2011.07.032

upstream raw materials:

7-hydroxy-3-methoxycarbonylmethyl-4-methyl-2H-chromen-2-one

methyl [4-methyl-7-(3',3'-dimethyl-2'-oxobutoxy)-2-oxo-2H-benzopyran-3-yl]-acetate

(3'-tert-butyl-5'-methyl-7'-oxo-7H-furo[3,2-g][1]benzopyran-6'-yl)acetic acid

L-phenylalanine

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