methyl (1R,3S,3aR,6aS)-4,6-dioxo-3-(o-chlorophenyl)-5-phenyl-octahydropyrrolo[3,4-c]pyrrole-1-carboxylate

Base Information

• Chemical Name: methyl (1R,3S,3aR,6aS)-4,6-dioxo-3-(o-chlorophenyl)-5-phenyl-octahydropyrrolo[3,4-c]pyrrole-1-carboxylate
• CAS No.: 1169983-20-3
• Molecular Formula: C₂₀H₁₇ClN₂O₄
• Molecular Weight: 384.819
• Mol file: 1169983-20-3.mol

Synonyms:methyl (1R,3S,3aR,6aS)-4,6-dioxo-3-(o-chlorophenyl)-5-phenyl-octahydropyrrolo[3,4-c]pyrrole-1-carboxylate

Chemical Property of methyl (1R,3S,3aR,6aS)-4,6-dioxo-3-(o-chlorophenyl)-5-phenyl-octahydropyrrolo[3,4-c]pyrrole-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (1R,3S,3aR,6aS)-4,6-dioxo-3-(o-chlorophenyl)-5-phenyl-octahydropyrrolo[3,4-c]pyrrole-1-carboxylate

There total 2 articles about methyl (1R,3S,3aR,6aS)-4,6-dioxo-3-(o-chlorophenyl)-5-phenyl-octahydropyrrolo[3,4-c]pyrrole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-phenyl-maleimide (941-69-5) + (E)-[(2-chloro-benzylidene)-amino]-acetic acid methyl ester (870083-18-4) → methyl (1S,3R,3aS,6aR)-4,6-dioxo-3-(o-chlorophenyl)-5-phenyl-octahydropyrrolo[3,4-c]pyrrole-1-carboxylate (939799-28-7) + methyl (1R,3S,3aR,6aS)-4,6-dioxo-3-(o-chlorophenyl)-5-phenyl-octahydropyrrolo[3,4-c]pyrrole-1-carboxylate (1169983-20-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; chiral 1,1'-binaphthyl-2,2'-diamine-based nickel(II) complex; In dichloromethane; at 15 ℃; for 24h; Title compound not separated from byproducts.;

DOI:10.1021/jo701561d

Reference yield:

N-phenyl-maleimide (941-69-5) + methyl [(2-chlorobenzylidene)amino]acetate (135998-78-6) → methyl (1R,3S,3aR,6aS)-4,6-dioxo-3-(o-chlorophenyl)-5-phenyl-octahydropyrrolo[3,4-c]pyrrole-1-carboxylate (1169983-20-3)

Guidance literature:

With (S)-TF-Biphamphos; silver(I) acetate; In dichloromethane; at 20 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1039/b902556a

upstream raw materials:

N-phenyl-maleimide

(E)-[(2-chloro-benzylidene)-amino]-acetic acid methyl ester

methyl [(2-chlorobenzylidene)amino]acetate