(R)-tert-butyl (1-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate

Base Information

Chemical Name:(R)-tert-butyl (1-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate
CAS No.:1500076-08-3
Molecular Formula:C₁₇H₂₁F₃N₄O₃
Molecular Weight:386.374
Hs Code.:

Synonyms:(R)-tert-butyl (1-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate

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Chemical Property of (R)-tert-butyl (1-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate

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Technology Process of (R)-tert-butyl (1-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate

There total 7 articles about (R)-tert-butyl (1-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1246221-03-3
(R)-tert-butyl (1-azido-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate

: 107-19-7
propargyl alcohol

: 1500076-08-3
(R)-tert-butyl (1-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate

Guidance literature:: With copper(l) iodide; sodium L-ascorbate; In water; tert-butyl alcohol; at 80 ℃; for 3h; Inert atmosphere;
DOI:10.1002/cmdc.201300104

Reference yield:

: 1246221-01-1
C₁₅H₂₀F₃NO₅S

: 1500076-08-3
(R)-tert-butyl (1-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 18 h / 67 °C

2: sodium L-ascorbate; copper(l) iodide / tert-butyl alcohol; water / 3 h / 80 °C / Inert atmosphere

With copper(l) iodide; sodium azide; sodium L-ascorbate; In water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/cmdc.201300104

Reference yield:

: 1500076-05-0
(Z)-methyl 2-((tert-butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)acrylate

: 1500076-08-3
(R)-tert-butyl (1-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 1,2-bis[(2R,5R)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; hydrogen / methanol / 18 h / 3750.38 Torr / Inert atmosphere

2: lithium borohydride / tetrahydrofuran / 2 h / 0 - 20 °C

3: triethylamine / dichloromethane / 0.5 h / 20 °C

4: sodium azide / N,N-dimethyl-formamide / 18 h / 67 °C

5: sodium L-ascorbate; copper(l) iodide / tert-butyl alcohol; water / 3 h / 80 °C / Inert atmosphere

With copper(l) iodide; lithium borohydride; sodium azide; 1,2-bis[(2R,5R)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; hydrogen; sodium L-ascorbate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/cmdc.201300104