N-(5'-bromo-3'-fluoro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-N-cyclopropyl-4-oxazol-5-ylbenzamide

Base Information

Chemical Name:N-(5'-bromo-3'-fluoro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-N-cyclopropyl-4-oxazol-5-ylbenzamide
CAS No.:1400707-87-0
Molecular Formula:C₂₃H₂₂BrFN₄O₂
Molecular Weight:485.356
Hs Code.:

Synonyms:N-(5'-bromo-3'-fluoro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-N-cyclopropyl-4-oxazol-5-ylbenzamide

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Chemical Property of N-(5'-bromo-3'-fluoro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-N-cyclopropyl-4-oxazol-5-ylbenzamide

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Technology Process of N-(5'-bromo-3'-fluoro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-N-cyclopropyl-4-oxazol-5-ylbenzamide

There total 5 articles about N-(5'-bromo-3'-fluoro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-N-cyclopropyl-4-oxazol-5-ylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89402-44-8
5-bromo-2,3-difluoropyridine

: 1400706-57-1
(N-cyclopropyl)-4-oxazol-5-yl-(N-piperidin-4-yl)benzamide

: 1400707-87-0
N-(5'-bromo-3'-fluoro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-N-cyclopropyl-4-oxazol-5-ylbenzamide

Guidance literature:: With potassium carbonate; In 1-methyl-pyrrolidin-2-one;

Reference yield:

: 179557-01-8
4-cyclopropylamino-piperidine-1-carboxylic acid tert-butyl ester

: 1400707-87-0
N-(5'-bromo-3'-fluoro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-N-cyclopropyl-4-oxazol-5-ylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one

With hydrogenchloride; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

Reference yield:

: 250161-45-6
4-(1,3-oxazol-5-yl)benzoic acid

: 1400707-87-0
N-(5'-bromo-3'-fluoro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-N-cyclopropyl-4-oxazol-5-ylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one

With hydrogenchloride; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;