6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-[(2-nitrophenyl)sulfonyl]-3-azabicyclo[4.1.0]hept-4-ene

Base Information

Chemical Name:6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-[(2-nitrophenyl)sulfonyl]-3-azabicyclo[4.1.0]hept-4-ene
CAS No.:1313875-10-3
Molecular Formula:C₂₀H₁₈Cl₂N₂O₅S
Molecular Weight:469.345
Hs Code.:

Synonyms:6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-[(2-nitrophenyl)sulfonyl]-3-azabicyclo[4.1.0]hept-4-ene

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Chemical Property of 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-[(2-nitrophenyl)sulfonyl]-3-azabicyclo[4.1.0]hept-4-ene

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Technology Process of 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-[(2-nitrophenyl)sulfonyl]-3-azabicyclo[4.1.0]hept-4-ene

There total 1 articles about 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-[(2-nitrophenyl)sulfonyl]-3-azabicyclo[4.1.0]hept-4-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1261604-86-7
N-[3-(3,4-dichlorophenyl)-2-propyn-1-yl]-N-{2-[(methyloxy)methyl]propen-1-yl}-2-nitrobenzenesulfonamide

: 1313875-10-3
6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-[(2-nitrophenyl)sulfonyl]-3-azabicyclo[4.1.0]hept-4-ene

: 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-[(2-nitrophenyl)sulfonyl]-3-azabicyclo[4.1.0]hept-4-ene

Guidance literature:: With silver tetrafluoroborate; dimethylsulfide gold(I) chloride; (R)-tol-BINAP; In toluene; at 25 ℃; for 5h; optical yield given as %ee; enantioselective reaction; Sealed vial; Inert atmosphere;
DOI:10.1021/jo102098y

Reference yield: 84.8%

: 1313875-10-3
6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-[(2-nitrophenyl)sulfonyl]-3-azabicyclo[4.1.0]hept-4-ene

: 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-[(2-nitrophenyl)sulfonyl]-3-azabicyclo[4.1.0]heptane

Guidance literature:: 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-[(2-nitrophenyl)sulfonyl]-3-azabicyclo[4.1.0]hept-4-ene; With rac-cysteine; In water; toluene; at 60 ℃; for 2h;

With triethylsilane; trifluoroacetic acid; In toluene; for 2h;
DOI:10.1021/jo102098y

Reference yield:

: 1313875-10-3
6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-[(2-nitrophenyl)sulfonyl]-3-azabicyclo[4.1.0]hept-4-ene

: (+/-)-GS⁽⁶⁰⁷⁾K₁₃₀₇F

Guidance literature:: Multi-step reaction with 3 steps

1.1: rac-cysteine / water; toluene / 2 h / 60 °C

1.2: 2 h

2.1: 3-mercaptopropionic acid; lithium hydroxide / N,N-dimethyl-formamide / 1 h / Inert atmosphere

3.1: phosphoric acid / propan-1-ol; water / 5 h / 25 - 80 °C

With rac-cysteine; phosphoric acid; 3-mercaptopropionic acid; lithium hydroxide; In propan-1-ol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo102098y