N-[3-(3,4-dichlorophenyl)-2-propyn-1-yl]-N-{2-[(methyloxy)methyl]propen-1-yl}-2-nitrobenzenesulfonamide

Base Information

Chemical Name:N-[3-(3,4-dichlorophenyl)-2-propyn-1-yl]-N-{2-[(methyloxy)methyl]propen-1-yl}-2-nitrobenzenesulfonamide
CAS No.:1261604-86-7
Molecular Formula:C₂₀H₁₈Cl₂N₂O₅S
Molecular Weight:469.345
Hs Code.:

Synonyms:N-[3-(3,4-dichlorophenyl)-2-propyn-1-yl]-N-{2-[(methyloxy)methyl]propen-1-yl}-2-nitrobenzenesulfonamide

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Chemical Property of N-[3-(3,4-dichlorophenyl)-2-propyn-1-yl]-N-{2-[(methyloxy)methyl]propen-1-yl}-2-nitrobenzenesulfonamide

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Technology Process of N-[3-(3,4-dichlorophenyl)-2-propyn-1-yl]-N-{2-[(methyloxy)methyl]propen-1-yl}-2-nitrobenzenesulfonamide

There total 3 articles about N-[3-(3,4-dichlorophenyl)-2-propyn-1-yl]-N-{2-[(methyloxy)methyl]propen-1-yl}-2-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 886883-34-7
3-chloro-2-[(methyloxy)methyl]-1-propene

: 1261604-85-6
N-[3-(3,4-dichlorophenyl)-2-propyn-1-yl]-2-nitrobenzenesulfonamide

: 1261604-86-7
N-[3-(3,4-dichlorophenyl)-2-propyn-1-yl]-N-{2-[(methyloxy)methyl]propen-1-yl}-2-nitrobenzenesulfonamide

Guidance literature:: N-[3-(3,4-dichlorophenyl)-2-propyn-1-yl]-2-nitrobenzenesulfonamide; With potassium carbonate; In N,N-dimethyl-formamide; for 0.333333h; Inert atmosphere;

3-chloro-2-[(methyloxy)methyl]-1-propene; In N,N-dimethyl-formamide; for 2h; Inert atmosphere;
DOI:10.1021/jo102098y

Reference yield:

: 908072-33-3
2-nitro-N-(prop-2-yn-1-yl)benzene-1-sulfonamide

: 1261604-86-7
N-[3-(3,4-dichlorophenyl)-2-propyn-1-yl]-N-{2-[(methyloxy)methyl]propen-1-yl}-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

2.2: 2 h / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; In N,N-dimethyl-formamide; 1.1: Sonogashira coupling;
DOI:10.1021/jo102098y

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 1261604-86-7
N-[3-(3,4-dichlorophenyl)-2-propyn-1-yl]-N-{2-[(methyloxy)methyl]propen-1-yl}-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 3.5 h / 0 - 25 °C / Inert atmosphere

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

3.2: 2 h / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 2.1: Sonogashira coupling;
DOI:10.1021/jo102098y