(4-amino-3-methoxyphenyl)dimethylphosphine oxide

Base Information

Chemical Name:(4-amino-3-methoxyphenyl)dimethylphosphine oxide
CAS No.:1197956-03-8
Molecular Formula:C₉H₁₄NO₂P
Molecular Weight:199.189
Hs Code.:

Synonyms:(4-amino-3-methoxyphenyl)dimethylphosphine oxide

Suppliers and Price of (4-amino-3-methoxyphenyl)dimethylphosphine oxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (4-amino-3-methoxyphenyl)dimethylphosphine oxide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (4-amino-3-methoxyphenyl)dimethylphosphine oxide

There total 3 articles about (4-amino-3-methoxyphenyl)dimethylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: (3-methoxy-4-nitrophenyl)(dimethyl)phosphane oxide

: 1197956-03-8
(4-amino-3-methoxyphenyl)dimethylphosphine oxide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; for 2h; under 1551.49 Torr;
DOI:10.1021/acs.jmedchem.6b00306

Reference yield: 33.0%

: 59557-91-4
4-bromo-2-methoxyaniline

: 7211-39-4
dimethyl phosphine oxide

: 1197956-03-8
(4-amino-3-methoxyphenyl)dimethylphosphine oxide

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In diethylene glycol dimethyl ether; at 140 ℃; for 12h;
DOI:10.1021/acs.joc.1c01413

Reference yield:

: 6627-53-8
1-chloro-3-methoxy-4-nitrobenzene

: 1197956-03-8
(4-amino-3-methoxyphenyl)dimethylphosphine oxide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; potassium phosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 18 h / 120 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / ethanol / 2 h / 1551.49 Torr

With potassium phosphate; palladium 10% on activated carbon; hydrogen; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b00306