tert-butyl [(5Z)-2-tert-butyl-5-{[(5-chloro-2-methoxyphenyl)carbonyl]imino}-3-methyl-2,5-dihydroisothiazol-4-yl]-carbamate

Base Information

Chemical Name:tert-butyl [(5Z)-2-tert-butyl-5-{[(5-chloro-2-methoxyphenyl)carbonyl]imino}-3-methyl-2,5-dihydroisothiazol-4-yl]-carbamate
CAS No.:1075244-01-7
Molecular Formula:C₂₁H₂₈ClN₃O₄S
Molecular Weight:453.99
Hs Code.:

Synonyms:tert-butyl [(5Z)-2-tert-butyl-5-{[(5-chloro-2-methoxyphenyl)carbonyl]imino}-3-methyl-2,5-dihydroisothiazol-4-yl]-carbamate

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Chemical Property of tert-butyl [(5Z)-2-tert-butyl-5-{[(5-chloro-2-methoxyphenyl)carbonyl]imino}-3-methyl-2,5-dihydroisothiazol-4-yl]-carbamate

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Technology Process of tert-butyl [(5Z)-2-tert-butyl-5-{[(5-chloro-2-methoxyphenyl)carbonyl]imino}-3-methyl-2,5-dihydroisothiazol-4-yl]-carbamate

There total 6 articles about tert-butyl [(5Z)-2-tert-butyl-5-{[(5-chloro-2-methoxyphenyl)carbonyl]imino}-3-methyl-2,5-dihydroisothiazol-4-yl]-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1075244-03-9
(5Z)-2-tert-butyl-5-{[(5-chloro-2-methoxyphenyl)carbonyl]imino}-3-methyl-2,5-dihydroisothiazole-4-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 1075244-01-7
tert-butyl [(5Z)-2-tert-butyl-5-{[(5-chloro-2-methoxyphenyl)carbonyl]imino}-3-methyl-2,5-dihydroisothiazol-4-yl]-carbamate

Guidance literature:: (5Z)-2-tert-butyl-5-{[(5-chloro-2-methoxyphenyl)carbonyl]imino}-3-methyl-2,5-dihydroisothiazole-4-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In 1,4-dioxane; at 80 ℃; for 3h;

tert-butyl alcohol; In 1,4-dioxane; at 80 ℃; for 8h;

Reference yield:

: 3438-16-2
5-chloro-2-methoxybenzoic acid

: 1075244-01-7
tert-butyl [(5Z)-2-tert-butyl-5-{[(5-chloro-2-methoxyphenyl)carbonyl]imino}-3-methyl-2,5-dihydroisothiazol-4-yl]-carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / toluene / 20 °C / Heating / reflux

2.1: tetrahydrofuran; acetone / 2 h / 20 °C

3.1: tetrahydrofuran / 2 h / 20 °C

3.2: 20 °C

4.1: sodium hydroxide; ethanol; water / 1,4-dioxane / 25 h / 20 °C

4.2: pH 4 / Acidic aqueous solution

5.1: diphenyl phosphoryl azide; triethylamine / 1,4-dioxane / 3 h / 80 °C

5.2: 8 h / 80 °C

With sodium hydroxide; thionyl chloride; ethanol; diphenyl phosphoryl azide; water; triethylamine; In tetrahydrofuran; 1,4-dioxane; acetone; toluene;

Reference yield:

: 76506-32-6
3-[(E)-tert-Butylimino]-butyric acid ethyl ester

: 1075244-01-7
tert-butyl [(5Z)-2-tert-butyl-5-{[(5-chloro-2-methoxyphenyl)carbonyl]imino}-3-methyl-2,5-dihydroisothiazol-4-yl]-carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 2 h / 20 °C

1.2: 20 °C

2.1: sodium hydroxide; ethanol; water / 1,4-dioxane / 25 h / 20 °C

2.2: pH 4 / Acidic aqueous solution

3.1: diphenyl phosphoryl azide; triethylamine / 1,4-dioxane / 3 h / 80 °C

3.2: 8 h / 80 °C

With sodium hydroxide; ethanol; diphenyl phosphoryl azide; water; triethylamine; In tetrahydrofuran; 1,4-dioxane;