[4-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-chlorophenyl]morpholinomethanone

Base Information

• Chemical Name: [4-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-chlorophenyl]morpholinomethanone
• CAS No.: 1617498-98-2
• Molecular Formula: C₂₁H₂₃ClN₆O₂
• Molecular Weight: 426.906
• Mol file: 1617498-98-2.mol

Synonyms:[4-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-chlorophenyl]morpholinomethanone

Chemical Property of [4-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-chlorophenyl]morpholinomethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-chlorophenyl]morpholinomethanone

There total 2 articles about [4-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-chlorophenyl]morpholinomethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.5%

[3-chloro-4-(morpholin-4-yl-carbonyl)phenyl]boronic acid (850589-49-0) + 5-bromo-3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-pyridin-2-ylamine (1617499-16-7) → [4-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-chlorophenyl]morpholinomethanone (1617498-98-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 120 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

5-bromo-3-ethynyl-pyridin-2-ylamine (1210838-82-6) → [4-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-chlorophenyl]morpholinomethanone (1617498-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium azide / water; tert-butyl alcohol / 2 h / 80 °C

1.2: 16 h / 80 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; caesium carbonate; In 1,4-dioxane; water; tert-butyl alcohol;

Reference yield: 67.7%

[4-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-chlorophenyl]morpholinomethanone (1617498-98-2) → 5-[3-chloro-4-(morpholinomethyl)phenyl]-3-(1-isopropyltriazol-4-yl)pyridin-2-amine (1617498-99-3)

Guidance literature:

[4-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-chlorophenyl]morpholinomethanone; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 70 ℃; for 4h;

With methanol; In tetrahydrofuran; at 0 - 70 ℃; for 6h;

upstream raw materials:

[3-chloro-4-(morpholin-4-yl-carbonyl)phenyl]boronic acid

5-bromo-3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-pyridin-2-ylamine

5-bromo-3-ethynyl-pyridin-2-ylamine

Downstream raw materials:

5-[3-chloro-4-(morpholinomethyl)phenyl]-3-(1-isopropyltriazol-4-yl)pyridin-2-amine