(2S)-(-)-1-(3',4'-dibenzyloxyphenoxy)-3-(2-(3'',4''-dimethoxyphenyl)ethylamino)-2-propanol

Base Information

• Chemical Name: (2S)-(-)-1-(3',4'-dibenzyloxyphenoxy)-3-(2-(3'',4''-dimethoxyphenyl)ethylamino)-2-propanol
• CAS No.: 782436-39-9
• Molecular Formula: C₃₃H₃₇NO₆
• Molecular Weight: 543.66
• Mol file: 782436-39-9.mol

Synonyms:(2S)-(-)-1-(3',4'-dibenzyloxyphenoxy)-3-(2-(3'',4''-dimethoxyphenyl)ethylamino)-2-propanol

Chemical Property of (2S)-(-)-1-(3',4'-dibenzyloxyphenoxy)-3-(2-(3'',4''-dimethoxyphenyl)ethylamino)-2-propanol

Chemical Property:

Purity/Quality:

(S)-1-(3,4-Bis(benzyloxy)phenoxy)-3-((3,4-dimethoxyphenethyl)amino)propan-2-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-(-)-1-(3',4'-dibenzyloxyphenoxy)-3-(2-(3'',4''-dimethoxyphenyl)ethylamino)-2-propanol

There total 6 articles about (2S)-(-)-1-(3',4'-dibenzyloxyphenoxy)-3-(2-(3'',4''-dimethoxyphenyl)ethylamino)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) + (2S)-(+)-1-(3',4'-dibenzyloxyphenoxy)-2,3-epoxypropane (177704-09-5) → (2S)-(-)-1-(3',4'-dibenzyloxyphenoxy)-3-(2-(3'',4''-dimethoxyphenyl)ethylamino)-2-propanol (782436-39-9)

Guidance literature:

In ethanol; at 80 - 85 ℃; for 5h;

DOI:10.1080/00397910600602651

Reference yield:

3,4-dibenzyloxybenzaldehyde (5447-02-9) → (2S)-(-)-1-(3',4'-dibenzyloxyphenoxy)-3-(2-(3'',4''-dimethoxyphenyl)ethylamino)-2-propanol (782436-39-9)

Guidance literature:

Multi-step reaction with 4 steps

1: m-chloroperbenzoic acid / CH₂Cl₂ / 0 °C

2: KOH / methanol / 0.5 h

3: NaH / dimethylformamide / 3 h / 5 °C

4: ethanol / 6 h / Heating

With potassium hydroxide; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Oxidation / 2: Hydrolysis / 3: Substitution / 4: Addition;

DOI:10.1016/S0223-5234(99)80103-2

Reference yield:

3,4-bis(benzyloxy)phenyl formate (189082-97-1) → (2S)-(-)-1-(3',4'-dibenzyloxyphenoxy)-3-(2-(3'',4''-dimethoxyphenyl)ethylamino)-2-propanol (782436-39-9)

Guidance literature:

Multi-step reaction with 3 steps

1: KOH / methanol / 0.5 h

2: NaH / dimethylformamide / 3 h / 5 °C

3: ethanol / 6 h / Heating

With potassium hydroxide; sodium hydride; In methanol; ethanol; N,N-dimethyl-formamide; 1: Hydrolysis / 2: Substitution / 3: Addition;

DOI:10.1016/S0223-5234(99)80103-2

upstream raw materials:

2-(3,4-dimethoxyphenyl)-ethylamine

(2S)-(+)-1-(3',4'-dibenzyloxyphenoxy)-2,3-epoxypropane

(S)-3-(3,4-dibenzyloxyphenoxy)-1,2-epoxypropane

3,4-dibenzyloxyphenol

Downstream raw materials:

(2S)-1-(3,4-dihydroxyphenoxy)-3-[2-(3',4'-dimethoxyphenyl)ethyl]amino-2-propanol