2-((3,4-Bis(benzyloxy)phenoxy)methyl)oxirane

Base Information

• Chemical Name: 2-((3,4-Bis(benzyloxy)phenoxy)methyl)oxirane
• CAS No.: 27688-87-5
• Molecular Formula: C23H22O4
• Molecular Weight: 362.425
• DSSTox Substance ID: DTXSID601240540
• Nikkaji Number: J2.357.386E
• Mol file: 27688-87-5.mol

Synonyms:2-((3,4-bis(benzyloxy)phenoxy)methyl)oxirane;27688-87-5;2-[[3,4-bis(phenylmethoxy)phenoxy]methyl]oxirane;2-{[3,4-bis(benzyloxy)phenoxy]methyl}oxirane;1,2-Dibenzyloxybenzen, 4-oxiranylmethoxy-;SCHEMBL8730039;DTXSID601240540;3,4-dibenzyloxyphenyl glycidyl ether;MFCD29913412;AKOS030524974;BS-27926;Glycidyl[3,4-bis(benzyloxy)phenyl] ether;1,2-Dibenzyloxybenzene, 4-oxiranylmethoxy-;3-(3,4-dibenzyloxyphenoxy)-1,2-epoxypropane;Y10576;2-([3,4-Bis(benzyloxy)phenoxy]methyl)oxirane #;A913179

Chemical Property of 2-((3,4-Bis(benzyloxy)phenoxy)methyl)oxirane

Chemical Property:

• PSA: 40.22000
• LogP: 4.62220
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• Exact Mass: 362.15180918
• Heavy Atom Count: 27
• Complexity: 417

Purity/Quality:

97% ^*data from raw suppliers

2-((3,4-Bis(benzyloxy)phenoxy)methyl)oxirane 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1C(O1)COC2=CC(=C(C=C2)OCC3=CC=CC=C3)OCC4=CC=CC=C4

Technology Process of 2-((3,4-Bis(benzyloxy)phenoxy)methyl)oxirane

There total 5 articles about 2-((3,4-Bis(benzyloxy)phenoxy)methyl)oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3,4-dibenzyloxyphenol (27688-86-4) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → (S)-3-(3,4-dibenzyloxyphenoxy)-1,2-epoxypropane (27688-87-5)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 20 ℃; for 15h;

DOI:10.1080/00397910600602651

Reference yield:

3,4-dibenzyloxybenzaldehyde (5447-02-9) → (S)-3-(3,4-dibenzyloxyphenoxy)-1,2-epoxypropane (27688-87-5)

Guidance literature:

Multi-step reaction with 3 steps

1: m-chloroperbenzoic acid / CH₂Cl₂ / 0 °C

2: KOH / methanol / 0.5 h

3: aq. KOH / ethanol

With potassium hydroxide; 3-chloro-benzenecarboperoxoic acid; In methanol; ethanol; dichloromethane; 1: Oxidation / 2: Hydrolysis / 3: Substitution;

DOI:10.1016/S0223-5234(99)80103-2

Reference yield:

3,4-bis(benzyloxy)phenyl formate (189082-97-1) → (S)-3-(3,4-dibenzyloxyphenoxy)-1,2-epoxypropane (27688-87-5)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / methanol / 0.5 h

2: aq. KOH / ethanol

With potassium hydroxide; In methanol; ethanol; 1: Hydrolysis / 2: Substitution;

DOI:10.1016/S0223-5234(99)80103-2

upstream raw materials:

3,4-dibenzyloxyphenol

epichlorohydrin

3,4-dibenzyloxybenzaldehyde

3,4-bis(benzyloxy)phenyl formate

Downstream raw materials:

OXY-Isoprenaline

N-<2-<<2-hydroxy-3-(3,4-dihydroxyphenoxy)propyl>amino>ethyl>-2-methylpropanamide

1-{2-[3-(3,4-Dihydroxy-phenoxy)-2-hydroxy-propylamino]-ethyl}-3-phenyl-urea

1-(3,4-dibenzyloxyphenoxy)-3-[2-(1,3,5-trimethylpyrimidine-2,4-dion-6-ylamino)-ethylamino]-propan-2-ol