2-[2-(4-fluorophenyl)ethyl]-7-hydroxy-4-nitro-2,3-dihydroisoindol-1-one

Base Information

Chemical Name:2-[2-(4-fluorophenyl)ethyl]-7-hydroxy-4-nitro-2,3-dihydroisoindol-1-one
CAS No.:474454-78-9
Molecular Formula:C₁₆H₁₃FN₂O₄
Molecular Weight:316.289
Hs Code.:

Synonyms:2-[2-(4-fluorophenyl)ethyl]-7-hydroxy-4-nitro-2,3-dihydroisoindol-1-one

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Chemical Property of 2-[2-(4-fluorophenyl)ethyl]-7-hydroxy-4-nitro-2,3-dihydroisoindol-1-one

Chemical Property:

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Technology Process of 2-[2-(4-fluorophenyl)ethyl]-7-hydroxy-4-nitro-2,3-dihydroisoindol-1-one

There total 7 articles about 2-[2-(4-fluorophenyl)ethyl]-7-hydroxy-4-nitro-2,3-dihydroisoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 474454-77-8
2-[2-(4-fluorophenyl)ethyl]-7-methoxy-4-nitro-2,3-dihydroisoindol-1-one

: 474454-78-9
2-[2-(4-fluorophenyl)ethyl]-7-hydroxy-4-nitro-2,3-dihydroisoindol-1-one

Guidance literature:: With boron tribromide; In dichloromethane; at 0 - 10 ℃;
DOI:10.1021/jm0202270

Reference yield:

: 81029-03-0
4-Methoxy-2,3-dimethylnitrobenzene

: 474454-78-9
2-[2-(4-fluorophenyl)ethyl]-7-hydroxy-4-nitro-2,3-dihydroisoindol-1-one

Guidance literature:: Multi-step reaction with 7 steps

1: 21 percent / H₂SO₄; CrO₃ / acetic acid / 2 h / 5 - 10 °C

2: 87 percent / NaOH / aq. ethanol / 2 h / Heating

3: 96 percent / KMnO₄; NaOH / H₂O / 2 h / Heating

4: 95 percent / methanol; hexane / 0.5 h / 20 °C

5: 53 percent / N-bromosuccinimide; dibenzoyl peroxide / CCl₄ / 13 h / Heating

6: 84 percent / triethylamine / methanol / Heating

7: 86 percent / BBr₃ / CH₂Cl₂ / 0 - 10 °C

With chromium(VI) oxide; sodium hydroxide; potassium permanganate; N-Bromosuccinimide; sulfuric acid; boron tribromide; triethylamine; dibenzoyl peroxide; In methanol; tetrachloromethane; ethanol; hexane; dichloromethane; water; acetic acid; 5: Wohl-Ziegler conditions;
DOI:10.1021/jm0202270

Reference yield:

: 474454-44-9
6-methoxy-2-methyl-3-nitrobenzyl alcohol

: 474454-78-9
2-[2-(4-fluorophenyl)ethyl]-7-hydroxy-4-nitro-2,3-dihydroisoindol-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / KMnO₄; NaOH / H₂O / 2 h / Heating

2: 95 percent / methanol; hexane / 0.5 h / 20 °C

3: 53 percent / N-bromosuccinimide; dibenzoyl peroxide / CCl₄ / 13 h / Heating

4: 84 percent / triethylamine / methanol / Heating

5: 86 percent / BBr₃ / CH₂Cl₂ / 0 - 10 °C

With sodium hydroxide; potassium permanganate; N-Bromosuccinimide; boron tribromide; triethylamine; dibenzoyl peroxide; In methanol; tetrachloromethane; hexane; dichloromethane; water; 3: Wohl-Ziegler conditions;
DOI:10.1021/jm0202270