2-[2-(4-fluorophenyl)ethyl]-7-methoxy-4-nitro-2,3-dihydroisoindol-1-one

Base Information

Chemical Name:2-[2-(4-fluorophenyl)ethyl]-7-methoxy-4-nitro-2,3-dihydroisoindol-1-one
CAS No.:474454-77-8
Molecular Formula:C₁₇H₁₅FN₂O₄
Molecular Weight:330.316
Hs Code.:

Synonyms:2-[2-(4-fluorophenyl)ethyl]-7-methoxy-4-nitro-2,3-dihydroisoindol-1-one

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Chemical Property of 2-[2-(4-fluorophenyl)ethyl]-7-methoxy-4-nitro-2,3-dihydroisoindol-1-one

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Technology Process of 2-[2-(4-fluorophenyl)ethyl]-7-methoxy-4-nitro-2,3-dihydroisoindol-1-one

There total 7 articles about 2-[2-(4-fluorophenyl)ethyl]-7-methoxy-4-nitro-2,3-dihydroisoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1583-88-6
4-fluoro-2-phenethylamine

: 474454-50-7
methyl 2-(bromomethyl)-6-methoxy-3-nitrobenzoate

: 474454-77-8
2-[2-(4-fluorophenyl)ethyl]-7-methoxy-4-nitro-2,3-dihydroisoindol-1-one

Guidance literature:: With triethylamine; In methanol; Heating;
DOI:10.1021/jm0202270

Reference yield:

: 81029-03-0
4-Methoxy-2,3-dimethylnitrobenzene

: 474454-77-8
2-[2-(4-fluorophenyl)ethyl]-7-methoxy-4-nitro-2,3-dihydroisoindol-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: 21 percent / H₂SO₄; CrO₃ / acetic acid / 2 h / 5 - 10 °C

2: 87 percent / NaOH / aq. ethanol / 2 h / Heating

3: 96 percent / KMnO₄; NaOH / H₂O / 2 h / Heating

4: 95 percent / methanol; hexane / 0.5 h / 20 °C

5: 53 percent / N-bromosuccinimide; dibenzoyl peroxide / CCl₄ / 13 h / Heating

6: 84 percent / triethylamine / methanol / Heating

With chromium(VI) oxide; sodium hydroxide; potassium permanganate; N-Bromosuccinimide; sulfuric acid; triethylamine; dibenzoyl peroxide; In methanol; tetrachloromethane; ethanol; hexane; water; acetic acid; 5: Wohl-Ziegler conditions;
DOI:10.1021/jm0202270

Reference yield:

: 474454-44-9
6-methoxy-2-methyl-3-nitrobenzyl alcohol

: 474454-77-8
2-[2-(4-fluorophenyl)ethyl]-7-methoxy-4-nitro-2,3-dihydroisoindol-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / KMnO₄; NaOH / H₂O / 2 h / Heating

2: 95 percent / methanol; hexane / 0.5 h / 20 °C

3: 53 percent / N-bromosuccinimide; dibenzoyl peroxide / CCl₄ / 13 h / Heating

4: 84 percent / triethylamine / methanol / Heating

With sodium hydroxide; potassium permanganate; N-Bromosuccinimide; triethylamine; dibenzoyl peroxide; In methanol; tetrachloromethane; hexane; water; 3: Wohl-Ziegler conditions;
DOI:10.1021/jm0202270