[4-amino-2-(methylsulfanyl)-1,3-thiazol-5-yl](3',4',5'-trimethoxyphenyl)methanone

Base Information

• Chemical Name: [4-amino-2-(methylsulfanyl)-1,3-thiazol-5-yl](3',4',5'-trimethoxyphenyl)methanone
• CAS No.: 1347690-25-8
• Molecular Formula: C₁₄H₁₆N₂O₄S₂
• Molecular Weight: 340.424

Synonyms:[4-amino-2-(methylsulfanyl)-1,3-thiazol-5-yl](3',4',5'-trimethoxyphenyl)methanone

Chemical Property of [4-amino-2-(methylsulfanyl)-1,3-thiazol-5-yl](3',4',5'-trimethoxyphenyl)methanone

Chemical Property:

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Technology Process of [4-amino-2-(methylsulfanyl)-1,3-thiazol-5-yl](3',4',5'-trimethoxyphenyl)methanone

There total 5 articles about [4-amino-2-(methylsulfanyl)-1,3-thiazol-5-yl](3',4',5'-trimethoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

1-(3,4,5-trimethoxyphenyl)-2-bromoethanone (51490-01-8) + dimethyl N-cyanodithioiminocarbonate (10191-60-3) → [4-amino-2-(methylsulfanyl)-1,3-thiazol-5-yl](3',4',5'-trimethoxyphenyl)methanone (1347690-25-8)

Guidance literature:

dimethyl N-cyanodithioiminocarbonate; With sodiumsulfide nonahydrate; In N,N-dimethyl-formamide; at 70 ℃; for 2h; Inert atmosphere;

1-(3,4,5-trimethoxyphenyl)-2-bromoethanone; In N,N-dimethyl-formamide; at 50 ℃; for 2h; Inert atmosphere;

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.10.013

Reference yield:

1-(3,4,5-trimethoxyphenyl)-2-bromoethanone (51490-01-8) + potassium S-methyl N-cyanocarbamodithioate (10191-61-4) → [4-amino-2-(methylsulfanyl)-1,3-thiazol-5-yl](3',4',5'-trimethoxyphenyl)methanone (1347690-25-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 3h;

Reference yield:

C18H18BrNO5 + potassium S-methyl N-cyanocarbamodithioate (10191-61-4) → [4-amino-2-(methylsulfanyl)-1,3-thiazol-5-yl](3',4',5'-trimethoxyphenyl)methanone (1347690-25-8)

Guidance literature:

In ethanol; at 20 ℃; for 0.333333h; regioselective reaction; Green chemistry;

DOI:10.1016/j.tetlet.2013.11.014

upstream raw materials:

1-(3,4,5-trimethoxyphenyl)-2-bromoethanone

dimethyl N-cyanodithioiminocarbonate

potassium S-methyl N-cyanocarbamodithioate

methyl (3,4,5-trimethoxyphenyl) ketone

Downstream raw materials:

(2,4-diamino-1,3-thiazol-5-yl)(3,4,5-trimethoxyphenyl)methanone

[4-amino-2-(dimethylamino)-1,3-thiazol-5-yl](3,4,5-trimethoxyphenyl)methanone

[4-amino-2-(diethylamino)-1,3-thiazol-5-yl](3,4,5-trimethoxyphenyl)methanone

(4-amino-2-phenylthiazol-5-yl)(3,4,5-trimethoxyphenyl)methanone

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