10191-61-4

Basic information

• Product Name: CYANIMIDODITHIOCARBONIC ACID MONOMETHYL ESTER MONOPOTASSIUM SALT
• Synonyms: CYANIMIDODITHIOCARBONIC ACID MONOMETHYL ESTER MONOPOTASSIUM SALT;CYANIMIDODITHIOCARBONIC ACID S-METHYL ESTER S-POTASSIUM SALT;Potassium methyl cyanoiminodithiocarbonate.;Cyanimidodithiocarbonic acid S-methyl ester;Cyanoimidodithiocarbonic acid S-methyl ester S-potassium salt;Cyanimidodithiocarbonic acid monomethyl estermonopotassium salt,98%;Potassium methyl cyanimidodithiocarbonate, Potassium (cyanoimino)(methylsulphanyl)methanethiolate, Potassium {[(methylthio)(sulphido)methylene]amino}(nitrilo)methane;Potassium methyl N-cyanocarbonodithioimidate 98%
• CAS NO: 10191-61-4
• Molecular Formula: C₃H₃N₂S₂*K
• Molecular Weight: 170.3
• Mol File: 10191-61-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 210-212 °C
• Boiling Point: 196.3°Cat760mmHg
• Flash Point: 72.5°C
• Appearance: Off-white to beige/Crystalline Powder
• Density: 1.332g/cm³
• Vapor Pressure: 0.401mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: CYANIMIDODITHIOCARBONIC ACID MONOMETHYL ESTER MONOPOTASSIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: CYANIMIDODITHIOCARBONIC ACID MONOMETHYL ESTER MONOPOTASSIUM SALT(10191-61-4)
• EPA Substance Registry System: CYANIMIDODITHIOCARBONIC ACID MONOMETHYL ESTER MONOPOTASSIUM SALT(10191-61-4)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 36/37/39-26
• Hazardous Substances Data: 10191-61-4(Hazardous Substances Data)

Usage

Chemical Properties

off-white to beige crystalline powder

InChI:InChI=1/C3H4N2S2/c1-7-3(6)5-2-4/h1H3,(H,5,6)

Upstream product

• 75-15-0 carbon disulfide 
• 420-04-2 CYANAMID 
• 74-88-4 methyl iodide 
• 13145-41-0 potassium cyanocarbonimidodithioate 

Downstream Products

• 63238-23-3 [3-(2,4-dinitro-phenyl)-4-oxo-thiazolidin-2-ylidene]-cyanamide 
• 60093-05-2 thiazole-5-carboxylic acid, 4-amino-2-methylthio-, methylester 
• 10191-69-2 ear double bond & ligand) 
• 63238-14-2 4-amino-N-methyl-2-(methylthio)-N-phenylthiazole-5-carboxamide 
• 60093-23-4 [3-(4-methoxy-phenyl)-4-oxo-thiazolidin-2-ylidene]-cyanamide 
• 63238-20-0 [3-(2,6-dimethyl-phenyl)-4-oxo-thiazolidin-2-ylidene]-cyanamide 
• 1557968-11-2 4-amino-2-benzyloxy-N-(naphthalen-2-yl)thiazole-5-carboxamide 
• 36602-95-6 S-benzyl-N-cyano-S’-methylcarbonimidodithioate 
• 63238-11-9 4-Amino-2-methylthio-5-thiazol-(N,N-pentamethylencarboxamid) 
• 1347690-25-8 [4-amino-2-(methylsulfanyl)-1,3-thiazol-5-yl](3',4',5'-trimethoxyphenyl)methanone 
• 39736-26-0 4-amino-5-acetyl-2-(methylthio)thiazole 
• 39736-29-3 ethyl 4-amino-2-(methylthio)thiazol-5-carboxylate 
• 39736-27-1 [4-amino-2-(methylthio)thiazole-5-yl](phenyl)methanone 
• 36602-94-5 N-cyano-dithiocarbonimidic acid methyl ester 4-nitro-benzyl ester 

Relevant articles and documents

Growth Factor Receptor antagonists. Preparation method and application thereof

The invention relates to a small molecule antagonist for transforming growth factor β receptors, a method for preparing the small molecule antagonist, and application of the small molecule antagonist in preparation of drugs. The small molecule antagonist for transforming the growth factor β receptor has the application of treating and/or preventing various diseases mediated by ALK5, and has great clinical application potential.

Synthesis method of ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate

The invention belongs to the technical field of pharmaceutical intermediates, and relates to a synthesis method of ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate. The method includes the followingsteps that an aqueous solution of cyanamide is mixed with ethanol, carbon disulfide and a potassium hydroxide solution are added for reaction, and a precipitated solid is subjected to suction filtration and drying to obtain an intermediate A; the intermediate A is dissolved in a mixed solution of ethanol and water, an iodomethane ethanol solution is dropped for reaction, and an intermediate B isobtained through concentration and drying; the intermediate B, ethyl chloroacetate and triethylamine are subjected to a reflux reaction in ethanol, and the obtained solution is concentrated, washed and re-crystallized to obtain ethyl 4-amino-2-(methylthio)thiazole-5-carboxylate. The cost of raw materials is low, the yield of by-products is low, the product yield is high, and the method is suitablefor scale-up production.

Thiazolopyridine analogs of nalidixic acid. 2. Thiazolo[4,5-b]pyridines

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