N-{3-[5-(S)-(4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

Base Information

Chemical Name:N-{3-[5-(S)-(4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide
CAS No.:1056901-19-9
Molecular Formula:C₂₄H₂₁FN₄O₆S₂
Molecular Weight:544.584
Hs Code.:

N-{3-[5-(S)-(4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ<SP>6</SP>-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

Synonyms:N-{3-[5-(S)-(4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

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Chemical Property of N-{3-[5-(S)-(4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

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Technology Process of N-{3-[5-(S)-(4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

There total 10 articles about N-{3-[5-(S)-(4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.4%

: 691361-76-9
2-amino-5-(methanesulfonylamino)benzenesulfonamide

: 1056901-32-6
5-(S)-(4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizine-7-carboxylic acid ethyl ester

: 1056901-19-9
N-{3-[5-(S)-(4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

Guidance literature:: 2-amino-5-(methanesulfonylamino)benzenesulfonamide; 5-(S)-(4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizine-7-carboxylic acid ethyl ester; In pyridine; at 120 ℃; for 4h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In pyridine; at 120 ℃; for 16h;

With citric acid; In water; ethyl acetate; at 25 ℃; pH=4;

Reference yield:

: 1056901-30-4
3-(S)-(4-fluoro-phenyl)-2-methyl-2-pyrrol-1-yl-propionic acid

: 1056901-19-9
N-{3-[5-(S)-(4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2.17 h / 0 - 25 °C

2.1: triethylamine; magnesium chloride / acetonitrile / 4 h / 0 - 50 °C

2.2: pH 6

3.1: methanesulfonic acid / 3.5 h / 0 - 25 °C

4.1: pyridine / 4 h / 120 °C

4.2: 16 h / 120 °C

4.3: 25 °C / pH 4

With oxalyl dichloride; methanesulfonic acid; triethylamine; magnesium chloride; N,N-dimethyl-formamide; In pyridine; dichloromethane; acetonitrile;

Reference yield:

: 96-73-1
2-chloro-5-nitro-benzenesulfonic acid

: 1056901-19-9
N-{3-[5-(S)-(4-fluoro-benzyl)-8-hydroxy-5-methyl-6-oxo-5,6-dihydro-indolizin-7-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 4 h / Heating / reflux

2.1: ammonia / tetrahydrofuran; water; toluene / 2 h / -10 °C

3.1: ammonia; ammonium carbonate; copper(II) sulfate / water / 4 h / 120 °C / pressure reaction vessel

4.1: hydrogen / nickel / tetrahydrofuran; methanol / 4 h / 25 °C / 2068.65 Torr

5.1: pyridine / dichloromethane / 19 h / 0 - 25 °C

6.1: pyridine / 4 h / 120 °C

6.2: 16 h / 120 °C

6.3: 25 °C / pH 4

With pyridine; thionyl chloride; ammonia; hydrogen; ammonium carbonate; copper(II) sulfate; nickel; N,N-dimethyl-formamide; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; toluene;