96-73-1

Basic information

• Product Name: 2-CHLORO-5-NITROBENZENESULFONIC ACID
• Synonyms: P-NITROCHLOROBENZENE-O-SULFONIC ACID;2-chloro-5-nitro-benzenesulfonicaci;2-CHLORO-5-NITROBENZENESULFONIC ACID;2-CHLORO-5-NITROBENZENESULPHONIC ACID;2-CHLORO-5-NITROSULFOBENZENE;4-NITROCHLOROBENZENE-2-SULFONIC ACID;Benzenesulfonic acid, 2-chloro-5-nitro-;2-chloro-5-nitrobenzene-1-sulfonic acid
• CAS NO: 96-73-1
• Molecular Formula: C₆H₄ClNO₅S
• Molecular Weight: 237.62
• EINECS: 202-528-9
• Product Categories: Intermediates of Dyes and Pigments;Aromatics;Heterocycles
• Mol File: 96-73-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: >300°C
• Appearance: /solid
• Density: 1.651 (estimate)
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: Refrigerator
• CAS DataBase Reference: 2-CHLORO-5-NITROBENZENESULFONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-NITROBENZENESULFONIC ACID(96-73-1)
• EPA Substance Registry System: 2-CHLORO-5-NITROBENZENESULFONIC ACID(96-73-1)

Safety Data

• Hazardous Substances Data: 96-73-1(Hazardous Substances Data)

Usage

Chemical Properties

Tan Solid

InChI:InChI=1/C6H4ClNO5S/c7-5-2-1-4(8(9)10)3-6(5)14(11,12)13/h1-3H,(H,11,12,13)

Upstream product

• 7664-93-9 sulfuric acid 
• 100-00-5 4-chlorobenzonitrile 
• 88-45-9 2,5-diaminobenzenesulfonic acid 
• 118-75-2 chloranil 

Downstream Products

• 88-35-7 2-anilino-5-nitro-benzenesulfonic acid 
• 79243-04-2 5-nitro-2-(4-nitro-phenylsulfanyl)-benzenesulfonic acid 
• 118272-23-4 2-(3-dimethylamino-anilino)-5-nitro-benzenesulfonic acid 
• 127204-97-1 2-chloro-5-nitro-4-cyanomethylbenzenesulfonic acid 
• 189025-22-7 2-[4-(4-amino-benzyl)-anilino]-5-nitro-benzenesulfonic acid 
• 121-33-5 vanillin 
• 936833-09-9 2-(3-ethoxyphenoxy)-5-nitrobenzenesulfonic acid 
• 936833-10-2 2-(2-ethoxyphenoxy)-5-nitrobenzenesulfonic acid 
• 1370347-11-7 N-(4-chloro-3-sulfamoylphenyl)pivalamide 
• 1370347-12-8 N-(4-chloro-3-sulfamoylphenyl)acrylamide 
• 1370347-13-9 2-chloro-N-(4-chloro-3-sulfamoylphenyl)propanamide 
• 1370347-14-0 2-(4-chloro-3-sulfamoylphenylamino)-2-oxoethyl acetate 
• 1370347-15-1 ethyl 2-(4-chloro-3-sulfamoylphenylamino)-2-oxoacetate 
• 1370347-16-2 N-(4-chloro-3-sulfamoylphenyl)-2,2,3,3,4,4,4-heptafluorobutanamide 

Relevant articles and documents

Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors

Glutathione transferase omega-1 (GSTO1-1) is an enzyme whose function supports the activation of interleukin (IL)-1β and IL-18 that are implicated in a variety of inflammatory disease states for which small-molecule inhibitors are sought. The potent reactivity of the active-site cysteine has resulted in reported inhibitors that act by covalent labeling. In this study, structure-activity relationship (SAR) elaboration of the reported GSTO1-1 inhibitor C1-27 was undertaken. Compounds were evaluated for inhibitory activity toward purified recombinant GSTO1-1 and for indicators of target engagement in cell-based assays. As covalent inhibitors, the kinact/KI values of selected compounds were determined, as well as in vivo pharmacokinetics analysis. Cocrystal structures of key novel compounds in complex with GSTO1-1 were also solved. This study represents the first application of a biochemical assay for GSTO1-1 to determine kinact/KI values for tested inhibitors and the most extensive set of cell-based data for a GSTO1-1 inhibitor SAR series reported to date. Our research culminated in the discovery of 25, which we propose as the preferred biochemical tool to interrogate cellular responses to GSTO1-1 inhibition.

METHODS AND COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS AND VIRAL INFECTIONS

The invention generally relates to methods and compounds for treating proliferative disorders, viral infections, or both. In some embodiments, the invention provides an anticancer or antiviral compound including a substituted nitro phenoxy phenyl, a sulfonylurea, and an alkyl group. In some embodiments, the invention provides a method of treating a proliferative disorder or a viral infection including administering an anticancer or antiviral compound that binds to a thromboxane receptor, has preferential binding for either TPalpha (TPα) or TPbeta (ΤΡβ) receptor subtype.

Reactive dyes having a triazine group which is substituted by hydrogen or an alkyl group

A water-soluble dye having a reactive group of the Formula (1): STR1 wherein: R1 is H or optionally substituted alkyl; R2 is H or C1-4 -alkyl; L is a divalent organic spacer group; and V is vinyl or a group convertible to vinyl on treatment with aqueous alkali. The reactive dyes of the present invention are useful for coloring natural and artificial textile materials containing amino or hydroxyl groups.