1,4-anhydro-3-O-(tert-butyldimethylsilyl)-5-O-(tert-butyldiphenylsilyl)-2-deoxy-D-erythro-pent-1-enitol

Base Information

Chemical Name:1,4-anhydro-3-O-(tert-butyldimethylsilyl)-5-O-(tert-butyldiphenylsilyl)-2-deoxy-D-erythro-pent-1-enitol
CAS No.:194672-69-0
Molecular Formula:C₂₇H₄₀O₃Si₂
Molecular Weight:468.784
Hs Code.:

Synonyms:1,4-anhydro-3-O-(tert-butyldimethylsilyl)-5-O-(tert-butyldiphenylsilyl)-2-deoxy-D-erythro-pent-1-enitol

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Chemical Property of 1,4-anhydro-3-O-(tert-butyldimethylsilyl)-5-O-(tert-butyldiphenylsilyl)-2-deoxy-D-erythro-pent-1-enitol

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Technology Process of 1,4-anhydro-3-O-(tert-butyldimethylsilyl)-5-O-(tert-butyldiphenylsilyl)-2-deoxy-D-erythro-pent-1-enitol

There total 7 articles about 1,4-anhydro-3-O-(tert-butyldimethylsilyl)-5-O-(tert-butyldiphenylsilyl)-2-deoxy-D-erythro-pent-1-enitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 128142-72-3
1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 194672-69-0
1,4-anhydro-3-O-(tert-butyldimethylsilyl)-5-O-(tert-butyldiphenylsilyl)-2-deoxy-D-erythro-pent-1-enitol

Guidance literature:: With 2,6-dimethylpyridine; N,O-bis-(trimethylsilyl)-acetamide; bis(diphenylthiophosphinoyl)amine; In n-heptane; toluene; at 100 ℃; for 3h; Inert atmosphere;
DOI:10.1021/acs.joc.1c00555

Reference yield:

: 3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-phenylselanyl-tetrahydro-furan

: 194672-69-0
1,4-anhydro-3-O-(tert-butyldimethylsilyl)-5-O-(tert-butyldiphenylsilyl)-2-deoxy-D-erythro-pent-1-enitol

Guidance literature:: With titanium(IV) isopropylate; tert.-butylhydroperoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;
DOI:10.1016/S0008-6215(01)00256-7

Reference yield:

: 101527-40-6
5'-O-tert-butyldiphenylsilylthymidine

: 194672-69-0
1,4-anhydro-3-O-(tert-butyldimethylsilyl)-5-O-(tert-butyldiphenylsilyl)-2-deoxy-D-erythro-pent-1-enitol

Guidance literature:: Multi-step reaction with 2 steps

1: imidazole / dimethylformamide

2: 59 percent / HMDS, (NH₄)2SO₄ / 4 h / Heating

With 1H-imidazole; ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; In N,N-dimethyl-formamide;
DOI:10.1021/jo970947s