4-[3-(1-cyanopiperidin-4-yl)propoxy]-2-methylbenzoic acid methyl ester

Base Information

• Chemical Name: 4-[3-(1-cyanopiperidin-4-yl)propoxy]-2-methylbenzoic acid methyl ester
• CAS No.: 1204301-93-8
• Molecular Formula: C₁₈H₂₄N₂O₃
• Molecular Weight: 316.4
• Mol file: 1204301-93-8.mol

Synonyms:4-[3-(1-cyanopiperidin-4-yl)propoxy]-2-methylbenzoic acid methyl ester

Chemical Property of 4-[3-(1-cyanopiperidin-4-yl)propoxy]-2-methylbenzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[3-(1-cyanopiperidin-4-yl)propoxy]-2-methylbenzoic acid methyl ester

There total 1 articles about 4-[3-(1-cyanopiperidin-4-yl)propoxy]-2-methylbenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromocyane (506-68-3) + 2-methyl-4-(3-piperidin-4-ylpropoxy)-benzoic acid methyl ester hydrochloride (1204301-94-9) → 4-[3-(1-cyanopiperidin-4-yl)propoxy]-2-methylbenzoic acid methyl ester (1204301-93-8)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water; at 0 - 20 ℃;

Reference yield:

4-[3-(1-cyanopiperidin-4-yl)propoxy]-2-methylbenzoic acid methyl ester (1204301-93-8) → 4-{3-[1-(N-hydroxycarbamimidoyl)piperidin-4-yl]propoxy}-2-methylbenzoic acid methyl ester (1204302-07-7)

Guidance literature:

With hydroxylamine; In ethanol; water; at 20 ℃;

Reference yield:

N-hydroxy-propionamidine (849833-55-2,29335-36-2,1217429-73-6) + 4-[3-(1-cyanopiperidin-4-yl)propoxy]-2-methylbenzoic acid methyl ester (1204301-93-8) → 4-{3-[1-(3-ethyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}-2-methyl-benzoic acid methyl ester (1204315-98-9)

Guidance literature:

N-hydroxy-propionamidine; 4-[3-(1-cyanopiperidin-4-yl)propoxy]-2-methylbenzoic acid methyl ester; With zinc(II) chloride; In tetrahydrofuran; diethyl ether; ethyl acetate; at 60 ℃; for 16h;

With hydrogenchloride; In methanol; water; at 65 ℃; for 5h;

With sodium hydrogencarbonate; In water; pH=7;

upstream raw materials:

bromocyane

2-methyl-4-(3-piperidin-4-ylpropoxy)-benzoic acid methyl ester hydrochloride

Downstream raw materials:

4-{3-[1-(3-ethyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}-2-methyl-benzoic acid methyl ester

4-{3-[1-(3-cyclopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}-2-methylbenzoic acid methyl ester

4-{3-[1-(3-cyclobutyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]propoxy}-2-methylbenzoic acid methyl ester

4-{3-[1-(N-hydroxycarbamimidoyl)piperidin-4-yl]propoxy}-2-methylbenzoic acid methyl ester