(R,E)-3-(4-bromophenyl)-1-(pyridazin-4-yl)-3-o-tolylpropan-1-one oxime

Base Information

Chemical Name:(R,E)-3-(4-bromophenyl)-1-(pyridazin-4-yl)-3-o-tolylpropan-1-one oxime
CAS No.:1434271-50-7
Molecular Formula:C₂₀H₁₈BrN₃O
Molecular Weight:396.286
Hs Code.:

Synonyms:(R,E)-3-(4-bromophenyl)-1-(pyridazin-4-yl)-3-o-tolylpropan-1-one oxime

Suppliers and Price of (R,E)-3-(4-bromophenyl)-1-(pyridazin-4-yl)-3-o-tolylpropan-1-one oxime

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R,E)-3-(4-bromophenyl)-1-(pyridazin-4-yl)-3-o-tolylpropan-1-one oxime

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R,E)-3-(4-bromophenyl)-1-(pyridazin-4-yl)-3-o-tolylpropan-1-one oxime

There total 7 articles about (R,E)-3-(4-bromophenyl)-1-(pyridazin-4-yl)-3-o-tolylpropan-1-one oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1434271-64-3
(R)-3-(4-bromophenyl)-1-(pyridazin-4-yl)-3-o-tolylpropan-1-one

: 1434271-50-7
(R,E)-3-(4-bromophenyl)-1-(pyridazin-4-yl)-3-o-tolylpropan-1-one oxime

Guidance literature:: With hydroxylamine hydrochloride; sodium hydrogencarbonate; In ethanol; water; at 120 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1434271-50-7
(R,E)-3-(4-bromophenyl)-1-(pyridazin-4-yl)-3-o-tolylpropan-1-one oxime

Guidance literature:: Multi-step reaction with 7 steps

1: piperidine / toluene / 5 h / Dean-Stark; Reflux

2: toluene; tetrahydrofuran / 2.83 h / 0 - 85 °C

3: sulfuric acid; acetic acid / 20.5 h / 27 °C / Cooling with ice; Reflux

4: 1,1'-carbonyldiimidazole / dichloromethane / 17 h / 20 °C

5: chiral HPLC (Reprosil Chiral-NR, heptane/2-propanol 80:20) / n-heptane; isopropyl alcohol / Resolution of racemate

6: zinc(II) iodide; phosphazene base-P₄-tert-butyl / tetrahydrofuran; hexane / 16 h / -78 - 20 °C

7: sodium hydrogencarbonate; hydroxylamine hydrochloride / ethanol; water / 0.17 h / 120 °C / Microwave irradiation

With piperidine; sulfuric acid; hydroxylamine hydrochloride; sodium hydrogencarbonate; acetic acid; phosphazene base-P₄-tert-butyl; 1,1'-carbonyldiimidazole; zinc(II) iodide; In tetrahydrofuran; ethanol; hexane; n-heptane; dichloromethane; water; isopropyl alcohol; toluene;

Reference yield:

: 1354808-42-6
ethyl 3-(4-bromophenyl)-2-cyano-3-o-tolylpropanoate

: 1434271-50-7
(R,E)-3-(4-bromophenyl)-1-(pyridazin-4-yl)-3-o-tolylpropan-1-one oxime

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; acetic acid / 20.5 h / 27 °C / Cooling with ice; Reflux

2: 1,1'-carbonyldiimidazole / dichloromethane / 17 h / 20 °C

3: chiral HPLC (Reprosil Chiral-NR, heptane/2-propanol 80:20) / n-heptane; isopropyl alcohol / Resolution of racemate

4: zinc(II) iodide; phosphazene base-P₄-tert-butyl / tetrahydrofuran; hexane / 16 h / -78 - 20 °C

5: sodium hydrogencarbonate; hydroxylamine hydrochloride / ethanol; water / 0.17 h / 120 °C / Microwave irradiation

With sulfuric acid; hydroxylamine hydrochloride; sodium hydrogencarbonate; acetic acid; phosphazene base-P₄-tert-butyl; 1,1'-carbonyldiimidazole; zinc(II) iodide; In tetrahydrofuran; ethanol; hexane; n-heptane; dichloromethane; water; isopropyl alcohol;