Tert-Butyl 6-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)-methyl]phenyl}acetyl]amino}heptanoate

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Chemical Name:Tert-Butyl 6-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)-methyl]phenyl}acetyl]amino}heptanoate
CAS No.:1242456-76-3
Molecular Formula:C₃₄H₄₅N₃O₅
Molecular Weight:575.748
Hs Code.:

Synonyms:Tert-Butyl 6-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)-methyl]phenyl}acetyl]amino}heptanoate

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Chemical Property of Tert-Butyl 6-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)-methyl]phenyl}acetyl]amino}heptanoate

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Technology Process of Tert-Butyl 6-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)-methyl]phenyl}acetyl]amino}heptanoate

There total 8 articles about Tert-Butyl 6-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)-methyl]phenyl}acetyl]amino}heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1176256-66-8
tert-butyl (+/-)-6-aminoheptanoate

: (+)-cyclopentyl{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetic acid

: 1242456-76-3
Tert-Butyl 6-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)-methyl]phenyl}acetyl]amino}heptanoate

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

Reference yield:

: 28669-17-2
2-phenyl-4H-1,3,4-oxadiazin-5(6H)-one

: 1242456-76-3
Tert-Butyl 6-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)-methyl]phenyl}acetyl]amino}heptanoate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: trifluoroacetic acid / dichloromethane

3: chiral silica gel phase based on the selector poly(N-methacryloyl-L-isoleucine-3-pentylamide) / ethyl acetate; 2-Methylpentane / 24 °C / Resolution of racemate

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; HATU / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

With benzotriazol-1-ol; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In 2-Methylpentane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 50677-24-2
Ν-p-methylbenzoyl-N'-chloroacetyl

: 1242456-76-3
Tert-Butyl 6-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)-methyl]phenyl}acetyl]amino}heptanoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 100 °C

2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

3: trifluoroacetic acid / dichloromethane

4: chiral silica gel phase based on the selector poly(N-methacryloyl-L-isoleucine-3-pentylamide) / ethyl acetate; 2-Methylpentane / 24 °C / Resolution of racemate

5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; HATU / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

With sodium hydrogencarbonate; benzotriazol-1-ol; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In 2-Methylpentane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;