methyl 4-<<5-(N'-cyclopentylureido)-1-methylindol-3-yl>methyl>-3-methoxybenzoate

Base Information

Chemical Name:methyl 4-<<5-(N'-cyclopentylureido)-1-methylindol-3-yl>methyl>-3-methoxybenzoate
CAS No.:107753-65-1
Molecular Formula:C₂₅H₂₉N₃O₄
Molecular Weight:435.523
Hs Code.:

Synonyms:methyl 4-<<5-(N'-cyclopentylureido)-1-methylindol-3-yl>methyl>-3-methoxybenzoate

Suppliers and Price of methyl 4-<<5-(N'-cyclopentylureido)-1-methylindol-3-yl>methyl>-3-methoxybenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 4-<<5-(N'-cyclopentylureido)-1-methylindol-3-yl>methyl>-3-methoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 4-<<5-(N'-cyclopentylureido)-1-methylindol-3-yl>methyl>-3-methoxybenzoate

There total 10 articles about methyl 4-<<5-(N'-cyclopentylureido)-1-methylindol-3-yl>methyl>-3-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 107754-14-3
methyl 4-<(5-amino-1-methylindol-3-yl)methyl>-3-methoxybenzoate

: 1003-03-8
Cyclopentamine

: 503-38-8
trichloromethyl chloroformate

: 107753-65-1
methyl 4-<<5-(N'-cyclopentylureido)-1-methylindol-3-yl>methyl>-3-methoxybenzoate

Guidance literature:: In 1,4-dioxane; methanol; dichloromethane;

Reference yield: 52.0%

: 4747-71-1
cyclopentyl isocyanate

: 107754-14-3
methyl 4-<(5-amino-1-methylindol-3-yl)methyl>-3-methoxybenzoate

: 107753-65-1
methyl 4-<<5-(N'-cyclopentylureido)-1-methylindol-3-yl>methyl>-3-methoxybenzoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 40 ℃; for 12h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.8b00458

Reference yield:

: 3556-83-0
methyl 4-methyl-3-methoxybenzoate

: 107753-65-1
methyl 4-<<5-(N'-cyclopentylureido)-1-methylindol-3-yl>methyl>-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / Reflux; Inert atmosphere

2: iron(III) chloride / 1,4-dioxane / 12 h / 20 °C / Inert atmosphere

3: hydrogen; palladium on activated charcoal / 12 h / 20 °C / Inert atmosphere

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 12 h / 40 °C / Inert atmosphere

With iron(III) chloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); palladium on activated charcoal; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; chloroform; 2: |Friedel-Crafts Alkylation;
DOI:10.1021/acs.jmedchem.8b00458