5-[4-(4-ethoxycarbonylmethyl-cyclohexyl)phenyl]-3-methyl-3H-[1,2,3]triazole-4-carboxylic acid

Base Information

Chemical Name:5-[4-(4-ethoxycarbonylmethyl-cyclohexyl)phenyl]-3-methyl-3H-[1,2,3]triazole-4-carboxylic acid
CAS No.:1396008-32-4
Molecular Formula:C₂₀H₂₅N₃O₄
Molecular Weight:371.436
Hs Code.:

Synonyms:5-[4-(4-ethoxycarbonylmethyl-cyclohexyl)phenyl]-3-methyl-3H-[1,2,3]triazole-4-carboxylic acid

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Chemical Property of 5-[4-(4-ethoxycarbonylmethyl-cyclohexyl)phenyl]-3-methyl-3H-[1,2,3]triazole-4-carboxylic acid

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Technology Process of 5-[4-(4-ethoxycarbonylmethyl-cyclohexyl)phenyl]-3-methyl-3H-[1,2,3]triazole-4-carboxylic acid

There total 9 articles about 5-[4-(4-ethoxycarbonylmethyl-cyclohexyl)phenyl]-3-methyl-3H-[1,2,3]triazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

: 1396008-31-3
5-[4-(4-ethoxycarbonylmethyl-cyclohexyl)phenyl]-3-methyl-3H-[1,2,3]triazole-4-carboxylic acid benzyl ester

: 1396008-32-4
5-[4-(4-ethoxycarbonylmethyl-cyclohexyl)phenyl]-3-methyl-3H-[1,2,3]triazole-4-carboxylic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 15h; Inert atmosphere;

Reference yield:

: 1396008-27-7
5-(4-bromophenyl)-3-methyl-3H-[1,2,3]triazole-4-carboxylic acid benzyl ester

: 1396008-32-4
5-[4-(4-ethoxycarbonylmethyl-cyclohexyl)phenyl]-3-methyl-3H-[1,2,3]triazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: zinc; chloro-trimethyl-silane; ethylene dibromide / tetrahydrofuran / 3 h / 20 - 60 °C / Neutral conditions

1.2: 5 h / 20 - 60 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 15 h / 20 °C / Inert atmosphere

With chloro-trimethyl-silane; palladium 10% on activated carbon; hydrogen; ethylene dibromide; zinc; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 766-96-1
4-bromo-1-ethynylbenzene

: 1396008-32-4
5-[4-(4-ethoxycarbonylmethyl-cyclohexyl)phenyl]-3-methyl-3H-[1,2,3]triazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -70 °C

1.2: 2 h / -70 - 20 °C

2.1: benzene / 4 h / Reflux

3.1: tetrabutyl ammonium fluoride; water / tetrahydrofuran / 0.17 h / 0 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

5.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

6.1: zinc; chloro-trimethyl-silane; ethylene dibromide / tetrahydrofuran / 3 h / 20 - 60 °C / Neutral conditions

6.2: 5 h / 20 - 60 °C / Inert atmosphere

7.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 15 h / 20 °C / Inert atmosphere

With chloro-trimethyl-silane; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydrogencarbonate; ethylene dibromide; lithium hydroxide; zinc; lithium diisopropyl amide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; benzene;