Technology Process of 5-[4-(4-ethoxycarbonylmethyl-cyclohexyl)phenyl]-3-methyl-3H-[1,2,3]triazole-4-carboxylic acid benzyl ester
There total 7 articles about 5-[4-(4-ethoxycarbonylmethyl-cyclohexyl)phenyl]-3-methyl-3H-[1,2,3]triazole-4-carboxylic acid benzyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(4-iodocyclohexyl)-acetic acid ethyl ester;
With
chloro-trimethyl-silane; ethylene dibromide; zinc;
In
tetrahydrofuran;
at 20 - 60 ℃;
for 3h;
Neutral conditions;
5-(4-bromophenyl)-3-methyl-3H-[1,2,3]triazole-4-carboxylic acid benzyl ester;
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane;
In
tetrahydrofuran;
at 20 - 60 ℃;
for 5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -70 °C
1.2: 2 h / -70 - 20 °C
2.1: benzene / 4 h / Reflux
3.1: tetrabutyl ammonium fluoride; water / tetrahydrofuran / 0.17 h / 0 °C
4.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C
5.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere
6.1: zinc; chloro-trimethyl-silane; ethylene dibromide / tetrahydrofuran / 3 h / 20 - 60 °C / Neutral conditions
6.2: 5 h / 20 - 60 °C / Inert atmosphere
With
chloro-trimethyl-silane; tetrabutyl ammonium fluoride; water; sodium hydrogencarbonate; ethylene dibromide; lithium hydroxide; zinc; lithium diisopropyl amide;
In
tetrahydrofuran; N,N-dimethyl-formamide; benzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: benzene / 4 h / Reflux
2.1: tetrabutyl ammonium fluoride; water / tetrahydrofuran / 0.17 h / 0 °C
3.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C
4.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere
5.1: zinc; chloro-trimethyl-silane; ethylene dibromide / tetrahydrofuran / 3 h / 20 - 60 °C / Neutral conditions
5.2: 5 h / 20 - 60 °C / Inert atmosphere
With
chloro-trimethyl-silane; tetrabutyl ammonium fluoride; water; sodium hydrogencarbonate; ethylene dibromide; lithium hydroxide; zinc;
In
tetrahydrofuran; N,N-dimethyl-formamide; benzene;
![5-(4-bromophenyl)-3-methyl-3H-[1,2,3]triazole-4-carboxylic acid benzyl ester](/Databaselist/images/loading.webp)
