1-{(2R,4R,5R)-4-Benzyloxy-5-benzyloxymethyl-4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-3-oxo-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-{(2R,4R,5R)-4-Benzyloxy-5-benzyloxymethyl-4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-3-oxo-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:207568-81-8
Molecular Formula:C₃₃H₄₄N₂O₇Si
Molecular Weight:608.807
Hs Code.:

1-{(2R,4R,5R)-4-Benzyloxy-5-benzyloxymethyl-4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-3-oxo-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Synonyms:1-{(2R,4R,5R)-4-Benzyloxy-5-benzyloxymethyl-4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-3-oxo-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-{(2R,4R,5R)-4-Benzyloxy-5-benzyloxymethyl-4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-3-oxo-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-{(2R,4R,5R)-4-Benzyloxy-5-benzyloxymethyl-4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-3-oxo-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

There total 3 articles about 1-{(2R,4R,5R)-4-Benzyloxy-5-benzyloxymethyl-4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-3-oxo-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 207568-78-3
1-{(2R,3R,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-3-hydroxy-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

: 207568-81-8
1-{(2R,4R,5R)-4-Benzyloxy-5-benzyloxymethyl-4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-3-oxo-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With dipyridinium dichromate; 3 A molecular sieve; acetic anhydride; In dichloromethane; for 1.5h; Ambient temperature;
DOI:10.1021/jo972239c

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 207568-81-8
1-{(2R,4R,5R)-4-Benzyloxy-5-benzyloxymethyl-4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-3-oxo-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / pyridine / 2 h / Ambient temperature

2: 91 percent / pyridinium dichromate, molecular sieves 3A, acetic anhydride / CH₂Cl₂ / 1.5 h / Ambient temperature

With pyridine; dipyridinium dichromate; 3 A molecular sieve; acetic anhydride; In dichloromethane;
DOI:10.1021/jo972239c

Reference yield:

: 199931-19-6
1-[3,5-Di-O-benzyl-3-C-(3-hydroxypropyl)-β-D-ribofuranosyl]thymine

: 207568-81-8
1-{(2R,4R,5R)-4-Benzyloxy-5-benzyloxymethyl-4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-3-oxo-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / pyridine / 2 h / Ambient temperature

2: 91 percent / pyridinium dichromate, molecular sieves 3A, acetic anhydride / CH₂Cl₂ / 1.5 h / Ambient temperature

With pyridine; dipyridinium dichromate; 3 A molecular sieve; acetic anhydride; In dichloromethane;
DOI:10.1021/jo972239c