Technology Process of dithiocarbonic acid O-[[3,5-bis-(3,3-dimethyl-but-1-ynyl)-4-[1,3]dioxolan-2-yl-phenyl]-(3,5-di-pent-1-ynyl-phenyl)-methyl] ester S-methyl ester
There total 15 articles about dithiocarbonic acid O-[[3,5-bis-(3,3-dimethyl-but-1-ynyl)-4-[1,3]dioxolan-2-yl-phenyl]-(3,5-di-pent-1-ynyl-phenyl)-methyl] ester S-methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
[3,5-bis-(3,3-dimethyl-but-1-ynyl)-4-[1,3]dioxolan-2-yl-phenyl]-(3,5-di-pent-1-ynyl-phenyl)-methanol;
With
1H-imidazole; sodium hydride;
In
tetrahydrofuran;
at 60 ℃;
for 0.5h;
carbon disulfide;
In
tetrahydrofuran;
at 60 ℃;
for 0.5h;
methyl iodide;
In
tetrahydrofuran;
for 0.5h;
DOI:10.1021/jo0349227
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 88 percent / NaOAc; ICl / acetic acid / 23 h / 80 °C
2.1: 43 percent / isoamylnitrite / dimethylformamide / 65 - 70 °C
3.1: 75 percent / CuI; Et3N / (Ph3P)2PdCl2 / tetrahydrofuran / 24 h / 20 °C
4.1: t-BuLi / tetrahydrofuran / 0.5 h / -78 °C
4.2: 38 percent / tetrahydrofuran / -78 - 20 °C
5.1: 71 percent / p-TsOH / toluene / 1 h / Heating
6.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
6.2: 78 percent / tetrahydrofuran / -78 - 20 °C
7.1: NaH; imidazole / tetrahydrofuran / 0.5 h / 60 °C
7.2: tetrahydrofuran / 0.5 h / 60 °C
7.3: 83 percent / tetrahydrofuran / 0.5 h
With
1H-imidazole; copper(l) iodide; n-butyllithium; tert.-butyl lithium; sodium acetate; Iodine monochloride; sodium hydride; toluene-4-sulfonic acid; triethylamine; isopentyl nitrite;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo0349227
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 75 percent / CuI; Et3N / (Ph3P)2PdCl2 / tetrahydrofuran / 24 h / 20 °C
2.1: t-BuLi / tetrahydrofuran / 0.5 h / -78 °C
2.2: 38 percent / tetrahydrofuran / -78 - 20 °C
3.1: 71 percent / p-TsOH / toluene / 1 h / Heating
4.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
4.2: 78 percent / tetrahydrofuran / -78 - 20 °C
5.1: NaH; imidazole / tetrahydrofuran / 0.5 h / 60 °C
5.2: tetrahydrofuran / 0.5 h / 60 °C
5.3: 83 percent / tetrahydrofuran / 0.5 h
With
1H-imidazole; copper(l) iodide; n-butyllithium; tert.-butyl lithium; sodium hydride; toluene-4-sulfonic acid; triethylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; toluene;
DOI:10.1021/jo0349227
