(E)-ethyl 2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetate

Base Information

• Chemical Name: (E)-ethyl 2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetate
• CAS No.: 1361001-00-4
• Molecular Formula: C₂₁H₁₉FO₂S
• Molecular Weight: 354.445
• Mol file: 1361001-00-4.mol

Synonyms:(E)-ethyl 2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetate

Chemical Property of (E)-ethyl 2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-ethyl 2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetate

There total 1 articles about (E)-ethyl 2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(E)-2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetic acid + ethanol (64-17-5) → (E)-ethyl 2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetate (1361001-00-4)

Guidance literature:

With sulfuric acid; for 20h; Inert atmosphere; Reflux;

DOI:10.1021/jm201528b

Reference yield: 56.0%

(E)-ethyl 2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetate (1361001-00-4) → (E)-2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetic acid

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 5h;

DOI:10.1021/jm201528b

Reference yield:

(E)-ethyl 2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetate (1361001-00-4) → (E)-2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)-N-(4-fluorophenylsulfonyl)acetamide (1361001-31-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 5 h / 20 °C

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 0 - 5 °C / Inert atmosphere

2.2: 20 h / Inert atmosphere

With 1,1'-carbonyldiimidazole; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/jm201528b

upstream raw materials:

ethanol

Downstream raw materials:

(E)-2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)-N-(4-fluorophenylsulfonyl)acetamide

(E)-2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)-N-(4-(trifluoromethyl)phenylsulfonyl)acetamide

(E)-2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)-N-(4-(trifluoromethoxy)phenylsulfonyl)acetamide

(E)-N-(5-chlorothiophen-2-ylsulfonyl)-2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetamide