diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride

Base Information

• Chemical Name: diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride
• CAS No.: 1393737-27-3
• Molecular Formula: C₂₂H₂₆BrNO₄*ClH
• Molecular Weight: 484.818
• Mol file: 1393737-27-3.mol

Synonyms:diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride

Chemical Property of diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride

There total 1 articles about diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate (1393737-35-3) → diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride (1393737-27-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; diethyl ether;

DOI:10.1016/j.tet.2012.06.090

Reference yield:

diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride (1393737-27-3) → (R)-[4-(4-bromobenzyl)-2-oxazolidinon-4-yl]methyl p-toluenesulfonate (1393737-52-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / water

2.1: lithium aluminium tetrahydride / diethyl ether / 2.5 h / Cooling with ice

2.2: 2 h / 20 °C

3.1: acetonitrile / 15 h / 20 °C

4.1: trifluorormethanesulfonic acid; methoxybenzene / nitromethane / 6 h / 50 °C

5.1: pyridine / 6 h / 0 - 20 °C

With pyridine; lithium aluminium tetrahydride; trifluorormethanesulfonic acid; sodium hydrogencarbonate; methoxybenzene; In diethyl ether; nitromethane; water; acetonitrile;

DOI:10.1016/j.tet.2012.06.090

Reference yield:

diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride (1393737-27-3) → (R)-3-(4-bromophenyl)-2-methyl-2-methylamino-1-propanol (1393737-30-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / water

2.1: lithium aluminium tetrahydride / diethyl ether / 2.5 h / Cooling with ice

2.2: 2 h / 20 °C

3.1: dmap; triethylamine / dichloromethane / 15 h / 20 °C

3.2: 6 h / 0 °C

4.1: trifluorormethanesulfonic acid; methoxybenzene / nitromethane / 6 h / 50 °C

5.1: pyridine / 6 h / 0 - 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Cooling with ice; Reflux

6.2: 19 h / 20 °C

With pyridine; dmap; lithium aluminium tetrahydride; trifluorormethanesulfonic acid; sodium hydrogencarbonate; methoxybenzene; triethylamine; In tetrahydrofuran; diethyl ether; nitromethane; dichloromethane; water;

DOI:10.1016/j.tet.2012.06.090

upstream raw materials:

diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate

Downstream raw materials:

(R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)-1,3-propanediol

(4S,αR)-4-(4-bromobenzyl)-4-hydroxymethyl-3-(α-methylbenzyl)-2-oxazolidinone

(4R,αR)-4-(4-bromobenzyl)-4-hydroxymethyl-3-(α-methylbenzyl)-2-oxazolidinone

(S)-4-(4-bromobenzyl)-4-hydroxymethyl-2-oxazolidinone