diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate

Base Information

• Chemical Name: diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate
• CAS No.: 1393737-35-3
• Molecular Formula: C₂₂H₂₆BrNO₄
• Molecular Weight: 448.357
• Mol file: 1393737-35-3.mol

Synonyms:diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate

Chemical Property of diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate

There total 2 articles about diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromomethyl-4-bromobenzene (589-15-1) + diethyl (R)-(α-methylbenzyl)aminomalonate (592531-06-1) → diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate (1393737-35-3)

Guidance literature:

diethyl (R)-(α-methylbenzyl)aminomalonate; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

1-bromomethyl-4-bromobenzene; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Cooling with ice;

DOI:10.1016/j.tet.2012.06.090

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) → diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate (1393737-35-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / acetonitrile / 18 h / 20 °C

1.2: Saturated solution

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 18 h / 20 °C / Cooling with ice

With potassium tert-butylate; triethylamine; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.tet.2012.06.090

Reference yield:

diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate (1393737-35-3) → diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride (1393737-27-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; diethyl ether;

DOI:10.1016/j.tet.2012.06.090

upstream raw materials:

(R)-1-phenyl-ethyl-amine

1-bromomethyl-4-bromobenzene

diethyl (R)-(α-methylbenzyl)aminomalonate

Downstream raw materials:

diethyl (R)-2-(4-bromobenzyl)-2-((α-methylbenzyl)amino)malonate hydrochloride

(4S,αR)-4-(4-bromobenzyl)-4-hydroxymethyl-3-(α-methylbenzyl)-2-oxazolidinone

(4R,αR)-4-(4-bromobenzyl)-4-hydroxymethyl-3-(α-methylbenzyl)-2-oxazolidinone

(S)-4-(4-bromobenzyl)-4-hydroxymethyl-2-oxazolidinone