{4-[3,5-Bis-(2,6-bis-hydroxymethyl-pyridin-4-yloxymethyl)-benzyloxy]-6-hydroxymethyl-pyridin-2-yl}-methanol

Base Information

• Chemical Name: {4-[3,5-Bis-(2,6-bis-hydroxymethyl-pyridin-4-yloxymethyl)-benzyloxy]-6-hydroxymethyl-pyridin-2-yl}-methanol
• CAS No.: 135075-20-6
• Molecular Formula: C₃₀H₃₃N₃O₉
• Molecular Weight: 579.607
• Mol file: 135075-20-6.mol

Synonyms:{4-[3,5-Bis-(2,6-bis-hydroxymethyl-pyridin-4-yloxymethyl)-benzyloxy]-6-hydroxymethyl-pyridin-2-yl}-methanol

Chemical Property of {4-[3,5-Bis-(2,6-bis-hydroxymethyl-pyridin-4-yloxymethyl)-benzyloxy]-6-hydroxymethyl-pyridin-2-yl}-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {4-[3,5-Bis-(2,6-bis-hydroxymethyl-pyridin-4-yloxymethyl)-benzyloxy]-6-hydroxymethyl-pyridin-2-yl}-methanol

There total 7 articles about {4-[3,5-Bis-(2,6-bis-hydroxymethyl-pyridin-4-yloxymethyl)-benzyloxy]-6-hydroxymethyl-pyridin-2-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Acetic acid 6-acetoxymethyl-4-[3,5-bis-(2,6-bis-acetoxymethyl-pyridin-4-yloxymethyl)-benzyloxy]-pyridin-2-ylmethyl ester (202803-31-4) → {4-[3,5-Bis-(2,6-bis-hydroxymethyl-pyridin-4-yloxymethyl)-benzyloxy]-6-hydroxymethyl-pyridin-2-yl}-methanol (135075-20-6)

Guidance literature:

With methanol; sodium methylate; for 2h; Heating;

DOI:10.1002/jhet.5570340635

Reference yield: 69.0%

1,3,5-Tris<<2,6-bis(methoxycarbonyl)-4-pyridinyloxy>methyl>-benzol (135075-19-3) → {4-[3,5-Bis-(2,6-bis-hydroxymethyl-pyridin-4-yloxymethyl)-benzyloxy]-6-hydroxymethyl-pyridin-2-yl}-methanol (135075-20-6)

Guidance literature:

With sodium tetrahydroborate; In ethanol; 1a) 0 deg C, 1 h, b) r. t., 3 h, c) reflux, 14 h;

Reference yield:

4-(benzyloxy)-2,6-bis(hydroxymethyl)pyridine (115148-04-4) → {4-[3,5-Bis-(2,6-bis-hydroxymethyl-pyridin-4-yloxymethyl)-benzyloxy]-6-hydroxymethyl-pyridin-2-yl}-methanol (135075-20-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / 4-dimethylaminopyridine, Et₃N / 2 h / Ambient temperature

2: 89 percent / H₂ / 10percent Pd/C / CH₂Cl₂ / 0.75 h / 0 °C

3: 1.) K₂CO₃ / 1.) DMF, 25 deg C, 30 min, 2.) DMF, from 70 deg C to 80 deg C, 24 h

4: 98 percent / NaOMe, MeOH / 2 h / Heating

With methanol; dmap; hydrogen; sodium methylate; potassium carbonate; triethylamine; palladium on activated charcoal; In dichloromethane;

DOI:10.1002/jhet.5570340635

upstream raw materials:

1,3,5-Tris<<2,6-bis(methoxycarbonyl)-4-pyridinyloxy>methyl>-benzol

Acetic acid 6-acetoxymethyl-4-[3,5-bis-(2,6-bis-acetoxymethyl-pyridin-4-yloxymethyl)-benzyloxy]-pyridin-2-ylmethyl ester

1,3,5-Tris(bromomethyl)benzene

4-(benzyloxy)-2,6-bis(hydroxymethyl)pyridine

Downstream raw materials:

1,3,5-Tris[(2,6-bis(chloromethyl)-4-pyridinyloxy)methyl]-benzol

C₅₁H₄₈N₆O₉S₃