1-(4-methoxybenzenesulfonyl)aziridin-3-(S)-(pyridin-3-yloxymethyl)aziridin-2-(R)-carbaldehyde

Base Information

Chemical Name:1-(4-methoxybenzenesulfonyl)aziridin-3-(S)-(pyridin-3-yloxymethyl)aziridin-2-(R)-carbaldehyde
CAS No.:370065-01-3
Molecular Formula:C₁₆H₁₆N₂O₅S
Molecular Weight:348.379
Hs Code.:

Synonyms:1-(4-methoxybenzenesulfonyl)aziridin-3-(S)-(pyridin-3-yloxymethyl)aziridin-2-(R)-carbaldehyde

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Chemical Property of 1-(4-methoxybenzenesulfonyl)aziridin-3-(S)-(pyridin-3-yloxymethyl)aziridin-2-(R)-carbaldehyde

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Technology Process of 1-(4-methoxybenzenesulfonyl)aziridin-3-(S)-(pyridin-3-yloxymethyl)aziridin-2-(R)-carbaldehyde

There total 6 articles about 1-(4-methoxybenzenesulfonyl)aziridin-3-(S)-(pyridin-3-yloxymethyl)aziridin-2-(R)-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 370065-00-2
[1-(4-methoxybenzenesulfonyl)aziridin-3-(S)-(pyridin-3-yloxymethyl)aziridin-2-(R)-yl]methanol

: 370065-01-3
1-(4-methoxybenzenesulfonyl)aziridin-3-(S)-(pyridin-3-yloxymethyl)aziridin-2-(R)-carbaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; for 1h;
DOI:10.1016/S0040-4020(01)00641-X

Reference yield:

: 370064-96-3
[1-benzyloxy-3-(S)-(pyridin-3-yloxymethyl)aziridine-2-(R)-yl]methanol

: 370065-01-3
1-(4-methoxybenzenesulfonyl)aziridin-3-(S)-(pyridin-3-yloxymethyl)aziridin-2-(R)-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

2: 97 percent / H₂ / Pd/BaSO₄ / ethanol / 14 h / 760 Torr

3: 97 percent / Et₃N / CH₂Cl₂ / 12 h / 0 °C

4: 81 percent / TBAF / tetrahydrofuran / 0.25 h / 0 °C

5: 92 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h

With 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; hydrogen; Dess-Martin periodane; triethylamine; Pd-BaSO₄; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/S0040-4020(01)00641-X

Reference yield:

: 370064-95-2
1-benzyloxy-3-(S)-(pyridin-3-yloxymethyl)aziridine-2-(R)-carboxylic acid tert-butyl ester

: 370065-01-3
1-(4-methoxybenzenesulfonyl)aziridin-3-(S)-(pyridin-3-yloxymethyl)aziridin-2-(R)-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / DIBALH / CH₂Cl₂; toluene / 1 h / -78 - 0 °C

2: 87 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

3: 97 percent / H₂ / Pd/BaSO₄ / ethanol / 14 h / 760 Torr

4: 97 percent / Et₃N / CH₂Cl₂ / 12 h / 0 °C

5: 81 percent / TBAF / tetrahydrofuran / 0.25 h / 0 °C

6: 92 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h

With 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; hydrogen; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; Pd-BaSO₄; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)00641-X