370064-95-2

Upstream product

• 264147-87-7 (E)-1-benzyloxy-3-(R)-[2-(1,3-dimethyl-2-oxo-4-(R)-5-(R)-[octahydro-2λ⁵-benzo[1.3.2]diazaphosphol-2-yl)vinyl]aziridine]-2-(R)-carboxylic acid tert-butyl ester 
• 109-00-2 3-HYDROXYPYRIDINE 
• 264147-90-2 1-benzyloxy-3-(S)-hydroxymethylaziridine-2-(R)-carboxylic acid tert-butyl ester 

Downstream Products

• 370065-03-5 1-(4-methoxybenzenesulfonyl)aziridin-3-(S)-(pyridin-3-yloxymethyl)aziridin-2-(R)-carboxylic acid benzyloxyamide 
• 370064-99-6 3-[3-(R)-(tert-butyldimethylsilanyloxymethyl)-1-(4-methoxybenzenesulfonyl)aziridin-2-(S)-ylmethoxy]pyridine 
• 370064-97-4 3-[1-benzyloxy-3-(R)-(tert-butyldimethylsilanyloxymethyl)aziridin-2-(S)-ylmethoxy]pyridine 
• 370065-02-4 1-(4-methoxybenzenesulfonyl)aziridin-3-(S)-(pyridin-3-yloxymethyl)aziridin-2-(R)-carboxylic acid 
• 370065-00-2 [1-(4-methoxybenzenesulfonyl)aziridin-3-(S)-(pyridin-3-yloxymethyl)aziridin-2-(R)-yl]methanol 
• 370065-01-3 1-(4-methoxybenzenesulfonyl)aziridin-3-(S)-(pyridin-3-yloxymethyl)aziridin-2-(R)-carbaldehyde 

Relevant academic research and scientific papers

Design and synthesis of MMP inhibitors using N-arylsulfonylaziridine hydroxamic acids as constrained scaffolds

The synthesis of cis- and trans-aziridine hydroxamic acid derivatives as MMP inhibitors is described using enantio- and diastereoselective methods for the formation of trisubstituted aziridines. Their preliminary inhibitory activity is reported and discus