N-Benzyloxycarbonyl-L-alanyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-L-prolyl-L-prolin-tert-butylester

Base Information

Chemical Name:N-Benzyloxycarbonyl-L-alanyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-L-prolyl-L-prolin-tert-butylester
CAS No.:126133-49-1
Molecular Formula:C₄₃H₆₁N₅O₁₆
Molecular Weight:903.981
Hs Code.:

Synonyms:N-Benzyloxycarbonyl-L-alanyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-L-prolyl-L-prolin-tert-butylester

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Chemical Property of N-Benzyloxycarbonyl-L-alanyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-L-prolyl-L-prolin-tert-butylester

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Technology Process of N-Benzyloxycarbonyl-L-alanyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-L-prolyl-L-prolin-tert-butylester

There total 9 articles about N-Benzyloxycarbonyl-L-alanyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-L-prolyl-L-prolin-tert-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 83283-35-6
Proline tert-butyl ester dibenzenesulfimide salt

: 126133-48-0
N-Benzyloxycarbonyl-L-alanyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-L-prolin

: 126133-49-1
N-Benzyloxycarbonyl-L-alanyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-L-prolyl-L-prolin-tert-butylester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; for 1h; Ambient temperature;

Reference yield:

: 1142-20-7
N-Cbz-Ala

: 126133-49-1
N-Benzyloxycarbonyl-L-alanyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-L-prolyl-L-prolin-tert-butylester

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / 2-ethoxy-1-(ethoxycarbonyl)-1,2-hydroquinoline / CH₂Cl₂ / 12 h / Ambient temperature

2: 865 mg / HCOOH / 24 h / Ambient temperature

3: 79 percent / 1-Hydroxybenzotriazol, N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimid-hydrochlorid / CH₂Cl₂; dimethylformamide / 16 h / Ambient temperature

4: 95 percent / HCOOH / 24 h

5: 91 percent / 1-hydroxybenzotriazole, N-(3-dimethylaminopropyl)-N'-ethylcarbodiimid-hydrochloride, Et₃N / CH₂Cl₂; dimethylformamide / 1 h / Ambient temperature

With formic acid; benzotriazol-1-ol; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 120791-78-8
O-(2-Acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonin-tert-butylester

: 126133-49-1
N-Benzyloxycarbonyl-L-alanyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-L-threonyl-L-prolyl-L-prolin-tert-butylester

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / 2-ethoxy-1-(ethoxycarbonyl)-1,2-hydroquinoline / CH₂Cl₂ / 12 h / Ambient temperature

2: 865 mg / HCOOH / 24 h / Ambient temperature

3: 79 percent / 1-Hydroxybenzotriazol, N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimid-hydrochlorid / CH₂Cl₂; dimethylformamide / 16 h / Ambient temperature

4: 95 percent / HCOOH / 24 h

5: 91 percent / 1-hydroxybenzotriazole, N-(3-dimethylaminopropyl)-N'-ethylcarbodiimid-hydrochloride, Et₃N / CH₂Cl₂; dimethylformamide / 1 h / Ambient temperature

With formic acid; benzotriazol-1-ol; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;