(2-chloropyrimidin-4-yl)-(2,3-difluoro-4-methoxybenzyl)amine

Base Information

• Chemical Name: (2-chloropyrimidin-4-yl)-(2,3-difluoro-4-methoxybenzyl)amine
• CAS No.: 1417883-88-5
• Molecular Formula: C₁₂H₁₀ClF₂N₃O
• Molecular Weight: 285.681
• Mol file: 1417883-88-5.mol

Synonyms:(2-chloropyrimidin-4-yl)-(2,3-difluoro-4-methoxybenzyl)amine

Chemical Property of (2-chloropyrimidin-4-yl)-(2,3-difluoro-4-methoxybenzyl)amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (2-chloropyrimidin-4-yl)-(2,3-difluoro-4-methoxybenzyl)amine

There total 1 articles about (2-chloropyrimidin-4-yl)-(2,3-difluoro-4-methoxybenzyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.72%

2,6-Dichloropyrimidine (3934-20-1) + (2,3-difluoro-4-methoxyphenyl)methanamine (886500-75-0) → (2-chloropyrimidin-4-yl)-(2,3-difluoro-4-methoxybenzyl)amine (1417883-88-5)

Guidance literature:

With triethylamine; In ethanol; at -20 - 20 ℃; for 5h;

Reference yield: 16.98%

5-methoxy-3-pyridinylboronic acid (850991-69-4) + (2-chloropyrimidin-4-yl)-(2,3-difluoro-4-methoxybenzyl)amine (1417883-88-5) → (2,3-difluoro-4-methoxybenzyl)-[2-(5-methoxypyridin-3-yl)pyrimidin-4-yl]amine (1417878-93-3)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate; In 1,4-dioxane; water; at 120 ℃; for 0.75h; Microwave irradiation;

upstream raw materials:

2,6-Dichloropyrimidine

(2,3-difluoro-4-methoxyphenyl)methanamine

Downstream raw materials:

(2,3-difluoro-4-methoxybenzyl)-[2-(5-methoxypyridin-3-yl)pyrimidin-4-yl]amine