1,4,5-triMethyl-2-phenyl-1H-iMidazole

Base Information

• Chemical Name: 1,4,5-triMethyl-2-phenyl-1H-iMidazole
• CAS No.: 152536-39-5
• Molecular Formula: C₁₂H₁₄N₂
• Molecular Weight: 186.257
• Mol file: 152536-39-5.mol

Synonyms:1,4,5-Trimethyl-2-phenylimidazole

Chemical Property of 1,4,5-triMethyl-2-phenyl-1H-iMidazole

Chemical Property:

• Boiling Point: 343.4±45.0 °C(Predicted)
• PKA: 7.44±0.60(Predicted)
• Density: 1.02±0.1 g/cm3(Predicted)

Purity/Quality:

98%Min ^*data from raw suppliers

1,4,5-Trimethyl-2-phenyl-1H-imidazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4,5-triMethyl-2-phenyl-1H-iMidazole

There total 4 articles about 1,4,5-triMethyl-2-phenyl-1H-iMidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-Methyl-N-<1-methyl-2-<<(methylamino)phenylmethylene>amino>-1-propenyl>benzamide → 1,4,5-Trimethyl-2-phenylimidazole (152536-39-5)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 12h; Heating;

DOI:10.1021/jo00077a033

Reference yield: 64.0%

1,4,5-Trimethylimidazole (20185-22-2) + sodium benzenesulfonate (873-55-2) → 1,4,5-Trimethyl-2-phenylimidazole (152536-39-5)

Guidance literature:

With tetrabutylammomium bromide; copper diacetate; palladium diacetate; In 1,4-dioxane; dimethyl sulfoxide; at 20 - 110 ℃; for 24.08h; Inert atmosphere;

DOI:10.1002/chem.201102644

Reference yield:

1,4,5-trimethyl-2-phenyl-1H-imidazole 3-oxide → 1,4,5-Trimethyl-2-phenylimidazole (152536-39-5)

Guidance literature:

With zinc; for 1h; Heating;

upstream raw materials:

benzaldehyde

1,4,5-Trimethylimidazole

sodium benzenesulfonate

Refernces

• 1、 Liu, Bo,Guo, Qiang,Cheng, Yangyang,Lan, Jingbo,You, Jingsong. "Palladium-catalyzed desulfitative C-H arylation of heteroarenes with sodium sulfinates". supporting information; experimental part. p. 13415 - 13419. Retrieved 2012/01/03.
• 2、 Lantos,Zhang,Shui,Eggleston. "Synthesis of imidazoles via hetero-cope rearrangements". . p. 7092 - 7095. Retrieved 2007/10/02.